Evidence mapPaperPMID 42332142Full record

ArticleNature medicine2026

Biological aging and generational shifts in early-onset cancer risk.

Ruiyi Tian, Xiaoyu Zong, Duo Ren, Stefani Tica, Daniel Hong, Oluseye Oduyale, Jason D Buenrostro, Ramaswamy Govindan, Yin Cao

Abstract read
PubMed Publisher
In one paragraph

Article in Nature medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruiyi TianDepartment of Surgery, Division of Public Health Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Xiaoyu ZongDepartment of Surgery, Division of Public Health Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Duo RenDepartment of Surgery, Division of Public Health Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Stefani TicaDepartment of Surgery, Division of Public Health Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-6935-9746
Daniel HongDepartment of Surgery, Division of Public Health Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0009-0007-5473-8990
Oluseye OduyaleDepartment of Surgery, Division of Public Health Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Jason D BuenrostroDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9958-3987
Ramaswamy GovindanAlvin J. Siteman Cancer Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Yin CaoDepartment of Surgery, Division of Public Health Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, USA. yin.cao@wustl.edu.ORCID http://orcid.org/0000-0001-9835-7662

Funding

Tissue Analysis Imaging CoreP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · 2000 to 2025
$13.7M
PROSPECT-Global Consortium and Risk Factor DiscoveryOT2CA297576 · WASHINGTON UNIVERSITY · 2025 to 2025
$1.4M
PROSPECT: Pathways, Risk factors, and mOleculeS to Prevent Early-onset Colorectal TumorsOT2CA297577 · HARVARD UNIVERSITY · 2025 to 2025
$614k
Obesity, sedentary behaviors, and diet quality for prevention and early detection of early-onset colorectal neoplasiaR37CA246175 · WASHINGTON UNIVERSITY · 2025 to 2025
$554k
Pediatric Gastroenterology Research Training ProgramT32DK077653 · WASHINGTON UNIVERSITY · 2025 to 2025
$512k
Molecular Oncology Training GrantT32CA113275 · WASHINGTON UNIVERSITY · 2025 to 2025
$363k
Cancer Research UK (CRUK) CGCATF-2023/100037Cancer Research UK (CRUK) CGCATF-2023/100043U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32CA113275U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32DK077653U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) OT2CA297576U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) OT2CA297577U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R37CA246175U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) P30DK052574WUSTL | Washington University School of Medicine in St. Louis UL1TR002345
6 · The paper itself

Abstract

Incidence of early-onset cancer is rising globally in recent generations, which underscores the need to elucidate the influence of emerging generational risk factors. Systemic and organ-specific aging reflects the cumulative impact of exposures and may provide an integrative and complementary approach to understand early-onset cancer risk. Here among 154,169 young adults from the United Kingdom Biobank, systemic aging measured by PhenoAge increased across birth cohorts, with 23% s.d. increase for those born 1965-1974 versus 1950-1954, and was associated with early-onset solid cancer risk (hazard ratio (HR)

Indexed as

AgingNeoplasmsAdultAge of OnsetFemaleHumansIncidenceLung NeoplasmsMaleMiddle AgedRisk FactorsUnited KingdomUnited StatesYoung Adult

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.