ArticleThe EMBO journal2026
OMA1 protects from liver injury and tumorigenesis during aging by controlling hepatic immunogenicity.
Yolanda Martí-Mateos, María Del Mar Muñoz-Hernández, Manuel M Gómez de Las Heras, José Ignacio Escrig-Larena, José Luis Cabrera-Alarcón, Rebeca Acín-Pérez, Enrique Calvo, Sara Natalia Jaroszewicz, Lucía de Prado-Rivas, Eva Raquel Martínez-Jiménez and 10 more
Abstract read
In one paragraphArticle in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
20 authors.
Yolanda Martí-MateosCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
María Del Mar Muñoz-HernándezCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Manuel M Gómez de Las HerasCentro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.
José Ignacio Escrig-LarenaCentro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.
Rebeca Acín-PérezCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Enrique CalvoCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Lucía de Prado-RivasCentro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.
Eva Raquel Martínez-JiménezCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Macarena De Andrés-LaguilloCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
José ViñaCentro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable. Instituto de salud Carlos III (CIBERFES), Madrid, Spain.
María MittelbrunnCentro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.ORCID http://orcid.org/0000-0003-3487-8762 María Concepción Jiménez-GómezCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Funding
Consejería de Educación, Juventud y Deporte, Comunidad de Madrid (Ministry of Education, Youth and Sports, Government of Madrid) Y2020/BIO-6350EC | European Research Council (ERC) ERC-2021-CoG-101044248EC | European Research Council (ERC) ERC-2024-ADG -GA 101198761'la Caixa' Foundation ('la Caixa') LCF/PR/HR23/52430010MEC | Instituto de Salud Carlos III (ISCIII) CB16/10/00282Ministerio de Ciencia, Innovación y Universidades (MCIU) MCIN/AEI /10.13039/501100011033Ministerio de Ciencia, Innovación y Universidades (MCIU) PID2021-1279880B-100Ministerio de Ciencia, Innovación y Universidades (MCIU) PID2024-158440OB-100Ministerio de Ciencia, Innovación y Universidades (MCIU) PRE2018-083478Ministerio de Ciencia, Innovación y Universidades (MCIU) TED2024-158440OB-I00
6 · The paper itselfAbstract
Hepatic inflammation and immunosurveillance play major roles in the progression of liver cancer. A common trigger for hepatic inflammation is oxidative stress, which stems from mitochondrial dysfunction. Here, we demonstrate that deletion of the mitochondrial stress integrator OMA1 increases hepatic primary tumor incidence and impairs survival in mice. Persistent activation of the KEAP1-Nrf2 oxidative stress pathway in the absence of OMA1 promotes early liver injury, which progresses into chronic hepatic inflammation and fibrosis during aging. Exhausted CD8
Indexed as
AgingCarcinogenesisLiverLiver NeoplasmsMitochondrial ProteinsAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHepatocytesKelch-Like ECH-Associated Protein 1MiceMice, Inbred C57BLMice, KnockoutNF-E2-Related Factor 2Oxidative StressSignal TransductionKeap1 protein, mouseKelch-Like ECH-Associated Protein 1Mitochondrial ProteinsNfe2l2 protein, mouseNF-E2-Related Factor 2
Identifiers
PMID42332198
PMCPMC13434532
What Socratic holds
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LicenceCC BY
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