Evidence map›Paper›PMID 42332243›Full record

ArticlePediatric research2026

Effects of 100% oxygen during deferred cord clamping on oxidative stress markers: a sub-study of a randomized controlled trial.

Anup C Katheria, Satyan Lakshminrusimha, Ana Morales, Felix Ines, Isabel Ten-Doménech, Julia Kuligowski, Abel Albiach-Delgado, Maximo Vento

Registry-linked trialAbstract read
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In one paragraph

Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04413097 (Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04413097 naactive not recruitingnot on this map

Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants

TypeinterventionalSponsorSharp HealthCareRan2021 to 2026Enrolled140ConditionsIVH- Intraventricular Hemorrhage, Extreme Prematurity, Hypoxia Neonatal, HyperoxiaArmsDelayed Cord Clamping with Low Oxygen concentration, Delayed Cord Clamping with High Oxygen concentration
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anup C KatheriaNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA, USA. anup.katheria@sharp.com.
Satyan LakshminrusimhaDepartment of Pediatrics, University of California, Davis, CA, USA.
Ana MoralesNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA, USA.
Felix InesNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA, USA.
Isabel Ten-DoménechSpanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS - SAMID) (RD24/0013/0014), Neonatal Research Group, Health Research Institute La Fe (IISLAFE), Valencia, Spain.
Julia KuligowskiSpanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS - SAMID) (RD24/0013/0014), Neonatal Research Group, Health Research Institute La Fe (IISLAFE), Valencia, Spain.
Abel Albiach-DelgadoSpanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS - SAMID) (RD24/0013/0014), Neonatal Research Group, Health Research Institute La Fe (IISLAFE), Valencia, Spain.
Maximo VentoSpanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS - SAMID) (RD24/0013/0014), Neonatal Research Group, Health Research Institute La Fe (IISLAFE), Valencia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe sought to evaluate oxidative changes in premature infants receiving 100% oxygen compared with 30% during deferred cord clamping (DCC).

methodsPremature infants born at 22

resultsSixty-eight infants had data available for analysis. The median (IQR) gestational age of infants was 26

conclusionBriefly providing 30% vs. 100% oxygen for 90 seconds during DCC showed no significant difference in GSH/GSSG ratios, but redox effects remain unclear given variability, sample size and limited power. Further studies are needed to ascertain potential oxidative damage during neonatal resuscitation and deferred cord clamping. THIS TRIAL IS REGISTERED ON CLINICALTRIALS. GOV ID: NCT04413097 IMPACT: The effect of oxygen administration during deferred cord clamping on redox status is unclear due to large variability in GSH and GSSG values and small sample size. These data provide some insights about umbilical arterial and venous oxygen levels and the effect of placenta on GSH/GSSG in preterm infants. Further basic and clinical studies are needed to better ascertain the potential for oxidative damage during neonatal resuscitation and deferred cord clamping.

Identifiers

PMID42332243

What Socratic holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.