Evidence map›Paper›PMID 42332333›Full record

ArticleFunctional & integrative genomics2026

Integration of transcriptome and mendelian randomization elucidates the protective role of aspirin in pulmonary tuberculosis development.

Wei Tan, Li Zhang, Shanmei Wang, Yu Chen, Hanqing Yu, Xinmiao Song, Changwei Wu, Ping Jiang, Shuo Liang

Abstract read
PubMed Publisher
In one paragraph

Article in Functional & integrative genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wei Tan *Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Li Zhang *Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Shanmei Wang *Department of Emergency, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Yu ChenDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Hanqing YuDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Xinmiao SongDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Changwei WuDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Ping JiangDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China. pingj67@126.com.
Shuo LiangDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China. liangshuo79@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPulmonary tuberculosis (PTB) is a chronic respiratory infectious disease with suboptimal treatment outcomes in some patients. The potential protective effect of aspirin against PTB and its underlying mechanisms remain unclear.

methodsTwo-sample Mendelian randomization (MR) was used to evaluate the association between aspirin use and PTB risk. Aspirin target genes from DrugBank were further assessed by summary-data-based Mendelian randomization (SMR) using eQTLGen and the Iceland dataset. Transcriptomic analysis compared gene expression between TB progressors and nonprogressors, and Kaplan-Meier analysis examined associations between gene expression and TB progression among household contacts. In vitro experiments were performed in BCG-stimulated monocytes.

resultsMR analysis showed that aspirin use was associated with reduced PTB risk (IVW: OR = 0.06, 95% CI: 0.01-0.51, p = 0.01). pQTL-based SMR identified significant associations of TNFAIP6 and NEU1 with PTB (p = 0.02, p-FDR = 0.03; p = 9.6 × 10⁻

conclusionThese findings suggest that aspirin may reduce PTB risk and implicate TNFAIP6 and NEU1 as potential mediators, supporting aspirin as a candidate adjunctive therapeutic strategy for PTB.

Indexed as

AspirinTranscriptomeTuberculosis, PulmonaryHumansMendelian Randomization AnalysisMonocytesQuantitative Trait LociAspirinAspirinMendelian randomizationNEU1Pulmonary tuberculosisSummary-data-based Mendelian randomizationTNFAIP6

Identifiers

PMID42332333

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.