Evidence map›Paper›PMID 42332580›Full record

ArticleBMC microbiology2026

Composite probiotics improve growth performance and enhance immune and antioxidant capacity in weaned yaks by modulating rumen microbiota and their metabolites.

Zhilong Wang, Shuxiang Wang, Long Ye, Jiyuan Zhang, Shengchun Xu, Yuxia Ding, Jiaming Wang, Yingkui Yang, Honglu Wang, Haisheng Shi and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zhilong WangQinghai University, Xining, 810016, China.
Shuxiang WangQinghai University, Xining, 810016, China.
Long YeQinghai University, Xining, 810016, China.
Jiyuan ZhangQinghai University, Xining, 810016, China.
Shengchun XuQinghai University, Xining, 810016, China.
Yuxia DingQinghai University, Xining, 810016, China.
Jiaming WangQinghai Provincial Animal Husbandry Station, Xining, 810016, China.
Yingkui YangQinghai University, Xining, 810016, China.
Honglu WangHuangyuan County Animal Husbandry and Veterinary Station, Xining, 810016, China.
Haisheng ShiHuangyuan County Animal Husbandry and Veterinary Station, Xining, 810016, China.
Chunye LiHuangyuan County Animal Husbandry and Veterinary Station, Xining, 810016, China.
Shatuo ChaiQinghai University, Xining, 810016, China.
Dongwen DaiQinghai University, Xining, 810016, China.
Jiaying LvQinghai University, Xining, 810016, China.
Yijuan MaQinghai University, Xining, 810016, China.
Xun WangQinghai University, Xining, 810016, China. wangxun513@163.com.

Funding

Qinghai Provincial Central Government-guided Local Science and Technology Development Fund 2024ZY049
6 · The paper itself

Abstract

backgroundAfter weaning, calves undergo a critical transition from liquid milk to solid feed. During this period, the digestive system is not yet fully mature and the rumen microbial community is still being established, which can easily lead to stress responses, growth retardation and other problems. Nutritional management and microecological regulation at this stage are crucial for rumen development, maturation of immune function and subsequent growth performance. Probiotics are regarded as an important nutritional and microecological strategy to alleviate weaning stress and promote the maturation of rumen and intestinal function. Therefore, in the present study, sixteen 8-month-old weaned yaks were randomly allocated to two groups (n = 8 per group): a composite probiotic group (CP) and a control group (CK). In the CP group, a composite probiotic preparation (Bacillus subtilis, Lactobacillus acidophilus and Bacillus licheniformis; viable count ≥ 1 × 10

resultsThe results showed that dietary supplementation with 0.2% compound probiotics significantly improved growth performance in weaned yaks, reduced serum urea nitrogen, increased serum catalase (CAT) activity, and decreased the pro-inflammatory cytokine IL-1β, thereby providing immune and oxidative-stress protection during the weaning-stress period. Rumen fermentation parameters indicated that the CP group had significantly lower NH

conclusionCompound probiotics may promote the enrichment of fiber-degrading bacteria such as Prevotellaceae_UCG_001, thereby simultaneously enhancing short-peptide supply and VFA production, which in turn increases microbial protein synthesis and reduces losses of NH

Indexed as

AntioxidantsGastrointestinal MicrobiomeProbioticsRumenAnimal FeedAnimalsBacillus licheniformisBacillus subtilisCattleDietDietary SupplementsFermentationLactobacillus acidophilusWeaningAntioxidantsAntioxidant capacityComposite probioticsGrowth performanceImmune functionRumen fermentationRumen metabolitesRumen microbiotaWeaned yaks

Identifiers

PMID42332580
PMCPMC13543509

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.