Evidence mapPaperPMID 42333003Full record

ArticleChemical biology & drug design2026

Biological and In Silico Evaluation of Novel Methoxyphenol-1,2,3-Triazole Hybrids as Multifunctional Anti-Alzheimer's and Anticancer Agents.

Sultan Onur, Mustafa Çeşme, Ferhan Tümer

Abstract read
In one paragraph

Article in Chemical biology & drug design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sultan OnurDepartment of Chemistry, Faculty of Sciences, Kahramanmaraş Sütçü İmam University, Kahramanmaras, Turkey.ORCID https://orcid.org/0000-0003-4305-9638
Mustafa ÇeşmeDepartment of Chemistry, Faculty of Sciences, Kahramanmaraş Sütçü İmam University, Kahramanmaras, Turkey.ORCID https://orcid.org/0000-0002-2020-5965
Ferhan TümerDepartment of Chemistry, Faculty of Sciences, Kahramanmaraş Sütçü İmam University, Kahramanmaras, Turkey.ORCID https://orcid.org/0000-0003-2222-2133

Funding

Kahramanmaraş Sütçü İmam University BAP-2022/3-25M
6 · The paper itself

Abstract

The development of multifunctional small molecules capable of simultaneously modulating multiple pathological pathways represents a rational strategy in medicinal chemistry for complex disorders such as Alzheimer's disease (AD) and cancer. Herein, a novel series of methoxyphenol-based 1,2,3-triazole hybrids (5a-h) was designed and synthesized via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). All derivatives were fully characterized by FT-IR,

Indexed as

Antineoplastic AgentsCholinesterase InhibitorsTriazolesAcetylcholinesteraseAlzheimer DiseaseAntioxidantsButyrylcholinesteraseCatalytic DomainCell Line, TumorCell ProliferationHumansMolecular Docking SimulationPC-3 CellsStructure-Activity RelationshipAcetylcholinesteraseAntineoplastic AgentsAntioxidantsButyrylcholinesteraseCholinesterase InhibitorsTriazolesanticancer activityantioxidant activitycholinesterase inhibitionin silicomethoxyphenolSARtriazole

Identifiers

PMID42333003
PMCPMC13287555

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.