ArticleJournal of inflammation research2026
Central Nervous System Involvement in Inflammatory Bowel Disease: A Bibliometric Analysis of Collaboration, Hotspots, and Research Trends.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Research on central nervous system (CNS) involvement in inflammatory bowel disease (IBD) has expanded rapidly, reflecting growing interest in the interaction between intestinal inflammation and brain-related disorders. This study aimed to systematically map the research landscape of IBD-related CNS involvement and to identify major research hotspots, intellectual structures, and emerging frontiers using bibliometric approaches. Methods: Publications related to IBD and CNS disorders were retrieved from the Web of Science Core Collection, between January 1, 2005, and December 31, 2024. Bibliometric and visualization analyses were conducted utilizing CiteSpace, VOSviewer, and Bibliometrix to evaluate publication trends, collaboration patterns, thematic evolution and historical development. Results: A total of 2,429 publications were included. The annual number of publications increased steadily from 2005 to 2024, with a marked acceleration after 2021, indicating increasing scholarly interest in this interdisciplinary field. Sixty-two countries/regions, 2,774 institutions, and 12,399 researchers have contributed to this field. The United States and China emerged as prominent contributors, with Mayo Clinic and Harvard Medical School recognized as central institutional centers. Thematic and keyword-based analyses revealed that research hotspots have evolved along three interrelated dimensions: a sustained focus on the gut-brain axis as the core mechanistic axis; an expansion of phenotypic profiling from general neurological involvement to a stratified central nervous system (CNS) phenotype spectrum; and a translational progression from descriptive correlations to precise predictions and targeted intervention. Conclusion: By integrating multiple bibliometric indicators, this study provides the developmental trajectory and thematic structure of IBD-related CNS research. The findings highlight that gut microbiota and gut-brain axis mechanisms as prominent emerging hotspot, while neurodegenerative disorders represent an expanding clinical frontier. Future studies should strengthen interdisciplinary collaboration, longitudinal cohort design, multimodal phenotyping, and mechanism-informed translational research.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.