PLGA/SF/linagliptin wound matrix-induced membrane promotes diabetic wounds healing by inhibiting macrophage pyroptosis.

Yizhuo Ren, Yanlong Wang, Kaixuan Cai, Xianzheng Lin, Tao Tang, Meng Yin

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Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Yizhuo RenDepartment of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.ORCID https://orcid.org/0009-0003-3516-7740

Yanlong WangDepartment of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

Kaixuan CaiDepartment of Burns and Plastic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

Xianzheng LinDepartment of Burns and Plastic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

Tao TangDepartment of Burns and Plastic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

Meng YinDepartment of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic wounds often exhibit delayed healing because of persistent inflammation, thus, remaining in the inflammatory phase. A key factor driving the delayed healing is pyroptosis, a proinflammatory form of programmed cell death which leads to the excessive release of inflammatory mediators. And macrophages are deeply involved in the entire process of wound inflammation. In this study, to regulate the pathological inflammation, we developed linagliptin-loaded hybrid PLGA [Poly(lactic-co-glycolic acid)]/SF(Silk Fibroin) membranes by electrostatic spinning. This advanced biomaterial with suitable physicochemical properties and biocompatibility is designed to provide a sustained release of linagliptin. Our

Indexed as

chronic inflammationDPP-4 inhibitorelectrospinningskin regeneration

Identifiers

PMID42333382

DOI10.1093/rb/rbag048

PMCPMC13283444

What Socratic holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.