Evidence map›Paper›PMID 42333513›Full record

ArticleCell cycle (Georgetown, Tex.)2026

OTUD5 promotes AML progression by stabilizing SLC7A11 to suppress ferroptosis.

Xiaowan Chen, Bingjie Zhao, Wenjing Yang, Zhenzhen Sun, Meng Hu, Pei Xu, Jia Guo, Tao Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaowan ChenLuoyang Key Laboratory of Transplantation and Immunological Studies for Haematological Diseases, Department of Clinical Laboratory, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Bingjie ZhaoDermatology and Venereology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Wenjing YangKey Laboratory of Molecular Medicine for Liver Injury and Repair, School of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, China.
Zhenzhen SunLuoyang Key Laboratory of Transplantation and Immunological Studies for Haematological Diseases, Department of Clinical Laboratory, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Meng HuLuoyang Key Laboratory of Transplantation and Immunological Studies for Haematological Diseases, Department of Hematology, the First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Pei XuLuoyang Key Laboratory of Transplantation and Immunological Studies for Haematological Diseases, Department of Clinical Laboratory, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Jia GuoLuoyang Key Laboratory of Transplantation and Immunological Studies for Haematological Diseases, Department of Clinical Laboratory, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Tao JiangLuoyang Key Laboratory of Transplantation and Immunological Studies for Haematological Diseases, Department of Clinical Laboratory, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is a highly aggressive malignancy with frequent therapeutic resistance, necessitating the identification of novel molecular targets. This study aims to elucidate the role of the deubiquitinase OTUD5 in AML progression by regulating SLC7A11 to suppress ferroptosis. We analyzed OTUD5 expression in AML patient samples and cell lines using RNA sequencing and quantitative PCR. Functional roles were assessed through OTUD5 silencing and overexpression in AML cell lines (THP-1, HL-60), followed by proliferation, colony formation, and ferroptosis assays (ROS, labile Fe

Indexed as

Amino Acid Transport System y+Disease ProgressionFerroptosisLeukemia, Myeloid, AcuteAnimalsCell Line, TumorCell ProliferationHL-60 CellsHumansMiceMice, NudeUbiquitinationAmino Acid Transport System y+SLC7A11 protein, humanAcute myeloid leukemia (AML)deubiquitinationferroptosisOTUD5SLC7A11

Identifiers

PMID42333513
PMCPMC13313254

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.