ArticlePsychological medicine2026
Depression and aging: insights from brain age prediction models.
Article in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundThe impact of depression on brain aging remains unclear, but both have been linked to stressful life events. Shared biological pathways may underlie structural brain changes. Clarifying these relationships could advance understanding of underlying mechanisms and inform treatment approaches.
methodsStructural MRI scans of 190 participants (controls,
resultsDepressed participants reported greater childhood maltreatment but a similar cortisol awakening response. An Age × Group interaction (
conclusionsMDD was associated with age-dependent differences in brain-PAD. The protective association between cortisol awakening response and brain age highlights the importance of integrating stress biomarkers to better understand neural aging mechanisms in depression.
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