ArticleOral health & preventive dentistry2026
Comparison of Salivary Stress Biomarkers in Patients with and without Periodontal Diseases: A Cross-sectional Study.
Article in Oral health & preventive dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study aimed to evaluate the salivary concentrations of cortisol (Cort), chromogranin A (CgA), and alpha-amylase (sAA) in periodontally healthy individuals and individuals with periodontal disease, and to investigate their association with perceived psychological stress, as measured by the Perceived Stress Scale (PSS). MATERIALS AND
methodsThe study included 400 participants aged ≥18 years (117 healthy participants, 140 with gingivitis, and 143 with periodontitis). Unstimulated salivary samples were collected from 90 participants systematically randomized from the 400 enrolled in this study. Subsequently, psychological stress was assessed using the PSS, and periodontal parameters were recorded. The ELISA test was used to measure salivary levels of Cort, CgA, and sAA.
resultsThe means of salivary cortisol concentrations were 33.54 (± 3.77 ng/ml) in controls, 65.89 (± 16.41 ng/ml) and 47.06 (± 4.55 ng/ml) in the gingivitis and periodontitis groups, respectively. Mean CgA concentrations were 724.75 (± 90.70 pg/ml) in controls, 1133.47 (± 302.49 pg/ml) in gingivitis, and 1526.30 (± 433.81 pg/ml) in periodontitis. Additionally, the mean of sAA levels was 24.40 (± 6.91 ng/ml) in the control group, 31.44 (± 3.91 ng/ml) and 34.13 (± 5.64 ng/ml) in the gingivitis and periodontitis groups, respectively. PSS scores were considerably higher in individuals with periodontal disease than in healthy controls.
conclusionSalivary levels of Cort, CgA, and sAA were elevated in individuals with periodontal disease compared to healthy controls. These biomarkers may serve as supportive indicators in the assessment of periodontal disease. However, further studies are required to validate these findings.
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