Evidence map›Paper›PMID 42333644›Full record

ArticleThe Cochrane database of systematic reviews2026

Preconception and first-trimester metformin for improving pregnancy outcomes in women with polycystic ovary syndrome.

Adam J Devall, James Cheshire, Nishanthi Periyathambi, Akanksha Garg, Kugajeevan Vigneswaran, Pedro Melo, Rima Dhillon-Smith, Arri Coomarasamy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Cochrane database of systematic reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adam J DevallNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.ORCID 0000-0001-5632-079X
James CheshireTommy's National Centre for Miscarriage Research, Department of Metabolism and Science, University of Birmingham, Birmingham, UK.
Nishanthi PeriyathambiTommy's National Centre for Miscarriage Research, Department of Metabolism and Science, University of Birmingham, Birmingham, UK.
Akanksha GargYale School of Medicine, Yale University, Connecticut, USA.
Kugajeevan VigneswaranNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Pedro MeloNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Rima Dhillon-SmithTommy's National Centre for Miscarriage Research, Department of Metabolism and Science, University of Birmingham, Birmingham, UK.
Arri CoomarasamyNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of metformin therapy initiated prior to conception and continued through the first trimester for women with polycystic ovary syndrome, compared with placebo or no metformin treatment, on pregnancy outcomes.

Indexed as

Hypoglycemic AgentsMetforminPolycystic Ovary SyndromePreconception CarePregnancy OutcomeFemaleHumansPregnancyPregnancy Trimester, FirstRandomized Controlled Trials as TopicSystematic Reviews as TopicHypoglycemic AgentsMetformin

Identifiers

PMID42333644
PMCPMC13288388

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.