Evidence mapPaperPMID 42333862Full record

ReviewJournal of applied biomedicine2026

Emerging biomedical and pharmaceutical strategies for the treatment of atherosclerosis: from conventional lipid-lowering therapy to nanomedicine.

Angelika Mysliwiec, Dawid Leksa, Dorota Bartusik-Aebisher, David Aebisher

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of applied biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Angelika MysliwiecUniversity of Rzeszow, Medical College, Faculty of Medicine, Department of Biochemistry and General Chemistry, 35-310 Rzeszow, Poland.ORCID 0009000106585471
Dawid LeksaRzeszow Center for Vascular and Endovascular Surgery, 35-310 Rzeszow, Poland.
Dorota Bartusik-AebisherUniversity of Rzeszow, Medical College, Faculty of Medicine, Department of Biochemistry and General Chemistry, 35-310 Rzeszow, Poland.ORCID 0000000255575464
David AebisherUniversity of Rzeszow, Medical College, Faculty of Medicine, Department of Photomedicine and Physical Chemistry, 35-310 Rzeszow, Poland.ORCID 0000000226616570

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerotic cardiovascular disease (ASCVD), including myocardial infarction and ischemic stroke, is a leading cause of death and disability worldwide and is expected to rise further by 2030. Once limited to industrialized nations, atherosclerosis has become a global issue due to the epidemiological transition from infectious to chronic metabolic diseases. Lipoproteins (chylomicrons, VLDL, LDL, HDL) and apolipoproteins play key roles in lipid metabolism and atherosclerosis development. Macrophages in plaques influence inflammation and plaque stability, with iron homeostasis also impacting disease progression. Therapies include personalized diets, statins, niacin, omega-3s, fibrates, and antiplatelet agents. Innovative strategies involve natural products and nanotechnology for targeted drug delivery, especially to macrophages and the endothelium, reducing systemic side effects. In summary, advancing therapies based on molecular insights and patient-specific factors are essential to combat this widespread chronic disease.

Indexed as

AtherosclerosisHypolipidemic AgentsNanomedicineAnimalsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHydroxymethylglutaryl-CoA Reductase InhibitorsHypolipidemic AgentsAtheroscleroticAtherosclerotic plaqueLipoproteinsNon-statin therapiesStatins

Identifiers

PMID42333862

What Socratic holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.