Evidence map›Paper›PMID 42333947›Full record

ArticleAging cell2026

Comparative Cochlear-Vestibular Aging Reveals Age-Aligned Mitochondrial Ultrastructural Burden, Mitophagy-Autophagy Remodeling, Synaptic Uncoupling, and Sensory Functional Decline.

Jingyi Xie, Xujia Zhang, Jinyi Tian, Yulu Yan, Ke Shi, Yongqi Pan, Yanni Zhang, Zichen Chen, Jianbin Sun, Hui Lv and 5 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jingyi XieThe Second Affiliated Hospital of Xi'an Jiaotong University, Department of Otorhinolaryngology-Head and Neck Surgery, Xi'an, China.
Xujia ZhangThe Second Affiliated Hospital of Xi'an Jiaotong University, Department of Otorhinolaryngology-Head and Neck Surgery, Xi'an, China.
Jinyi TianThe Second Affiliated Hospital of Xi'an Jiaotong University, Department of Otorhinolaryngology-Head and Neck Surgery, Xi'an, China.
Yulu YanThe Second Affiliated Hospital of Xi'an Jiaotong University, Department of Otorhinolaryngology-Head and Neck Surgery, Xi'an, China.
Ke ShiThe Second Affiliated Hospital of Xi'an Jiaotong University, Department of Otorhinolaryngology-Head and Neck Surgery, Xi'an, China.
Yongqi PanThe Second Affiliated Hospital of Xi'an Jiaotong University, Department of Otorhinolaryngology-Head and Neck Surgery, Xi'an, China.
Yanni ZhangThe Second Affiliated Hospital of Xi'an Jiaotong University, Department of Otorhinolaryngology-Head and Neck Surgery, Xi'an, China.
Zichen ChenThe Second Affiliated Hospital of Xi'an Jiaotong University, Department of Otorhinolaryngology-Head and Neck Surgery, Xi'an, China.
Jianbin SunThe Second Affiliated Hospital of Xi'an Jiaotong University, Department of Otorhinolaryngology-Head and Neck Surgery, Xi'an, China.
Hui LvThe Second Affiliated Hospital of Xi'an Jiaotong University, Department of Otorhinolaryngology-Head and Neck Surgery, Xi'an, China.
Jingguo ChenThe Second Affiliated Hospital of Xi'an Jiaotong University, Department of Otorhinolaryngology-Head and Neck Surgery, Xi'an, China.ORCID https://orcid.org/0000-0002-7051-4037
Xiaoyong RenThe Second Affiliated Hospital of Xi'an Jiaotong University, Department of Otorhinolaryngology-Head and Neck Surgery, Xi'an, China.ORCID https://orcid.org/0000-0001-6062-2977
Teru KamogashiraDepartment of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Xiaotong ZhangThe Second Affiliated Hospital of Xi'an Jiaotong University, Department of Otorhinolaryngology-Head and Neck Surgery, Xi'an, China.
Ying GaoThe Second Affiliated Hospital of Xi'an Jiaotong University, Department of Otorhinolaryngology-Head and Neck Surgery, Xi'an, China.

Funding

IIT Clinical Research Fund of The Second Affiliated Hospital of Xi'an Jiaotong University M020the Institute Foundation's Free Exploration Project of the Second Affiliated Hospital of Xi'an Jiaotong University 2020YJ(ZYTS)043the National Natural Science Foundation of China 82101224the Xi'an Jiaotong University Education Foundation XJYG2025-SFJJ2032
6 · The paper itself

Abstract

Age-related hearing loss and balance decline are prevalent features of organismal aging, yet how the cochlea and vestibular organs converge on shared cellular liabilities remains insufficiently resolved. In particular, whether mitochondrial ultrastructural injury and mitochondrial quality-control programs co-vary with synaptic vulnerability and sensory functional decline across these systems within an age-resolved framework has not been clearly delineated. Here, we compared cochlear and vestibular aging in SAMP8 mice of different ages using integrated functional assays, region-resolved quantification of hair cells and CtBP2/GluA2 synapses, cochlear NF200+ fiber area fraction, transmission electron microscopy, and targeted qPCR of mitophagy/autophagy-lysosome genes. The results show that ABR thresholds rose progressively across 5.6-32 kHz. VsEP exhibited age-dependent threshold shifts and prolonged P-wave latency. Relative to the magnitude of synaptic and functional changes, cochlear hair-cell numbers were broadly preserved, although regional OHC loss was observed in middle-to-basal turns, whereas vestibular macular hair-cell density declined with age. Ultrastructurally, the proportion of pathological mitochondria increased with age, featuring electron-lucent matrix, disrupted cristae organization, and rounded/swollen profiles. What's more, guided by an adult-versus-aged transcriptomic screen nominating the Ca

Indexed as

AgingAutophagyCochleaMitochondriaMitophagySynapsesAnimalsMiceage‐related sensory declinecochlea–vestibular agingmitochondrial ultrastructural injurymitophagy–autophagy remodelingsynaptic uncoupling

Identifiers

PMID42333947
PMCPMC13288170

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.