Evidence map›Paper›PMID 42333965›Full record

ArticleJournal of food science2026

Characterization and Bioactivity of Nanovesicles Recovered From Industrial Cheesemaking Whey Wastewater.

Raffaella Latella, Anna Sansone, Carla Emiliani, Carla Ferreri, Letizia Mezzasoma, Rita Romani, Marco Gargaro, Roberto Maria Pellegrino, Husam B R Alabed, Eleonora Calzoni and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of food science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Raffaella LatellaDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
Anna SansoneISOF, Institute for Organic Synthesis and Photoreactivity, Consiglio Nazionale delle Ricerche, Bologna, Italy.
Carla EmilianiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
Carla FerreriISOF, Institute for Organic Synthesis and Photoreactivity, Consiglio Nazionale delle Ricerche, Bologna, Italy.
Letizia MezzasomaDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Rita RomaniDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Marco GargaroDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Roberto Maria PellegrinoDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
Husam B R AlabedDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
Eleonora CalzoniDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
Stefano GiovagnoliDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Luana LuginiDepartment of Oncology and Molecular Medicine, Preclinical Research and Clinical Trials in Hematology and Oncology Unit, Istituto Superiore di Sanità, Rome, Italy.
Cristina FedericiDepartment of Oncology and Molecular Medicine, Preclinical Research and Clinical Trials in Hematology and Oncology Unit, Istituto Superiore di Sanità, Rome, Italy.
Federica FratiniCore Facility, Istituto Superiore di Sanità, Rome, Italy.
Lorena UrbanelliDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
Sandra BurattaDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.ORCID https://orcid.org/0000-0002-9875-0138

Funding

European Commission
6 · The paper itself

Abstract

Food-derived nanovesicles (NVs), and particularly, those derived from milk, are considered promising nutraceutical candidates and potential carriers for drug delivery. Here, as an alternative to milk, we used a dairy byproduct as a source of NVs. Specifically, we isolated and characterized NVs from cheese whey wastewater (WWW) generated during the Grana Padano cheese production. The results of this study demonstrated that WWW-NVs shared key features with milk-derived vesicles in terms of biophysical properties (mean size <200 nm and negative zeta potential) and membrane lipid composition, characterized by the high content of phosphatidylcholine and sphingomyelin. WWW-NVs were efficiently internalized by monocytic THP-1 cells. In H

Indexed as

CheeseIndustrial WasteWastewaterWheyAnimalsCell SurvivalHumansReactive Oxygen SpeciesTHP-1 CellsIndustrial WasteReactive Oxygen SpeciesWastewater

Identifiers

PMID42333965
PMCPMC13288309

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.