Evidence map›Paper›PMID 42334309›Full record

ArticleAnnals of medicine2026

The impact of multiple long-term conditions on mortality, progression to kidney failure and health-related quality of life among people with chronic kidney disease: a multicentre cohort study (NURTuRE-CKD).

Irene Boateng, Thomas Phillips, Scott Harris, Olalekan Lee Aiyegbusi, Paul Cockwell, Philip A Kalra, Thomas McDonnell, Beth Lucas, Paul J Roderick, David C Wheeler and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Irene BoatengSchool of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.ORCID 0000-0002-8862-6678
Thomas PhillipsSchool of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.ORCID 0000-0001-6059-745X
Scott HarrisSchool of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.ORCID 0000-0001-5774-1537
Olalekan Lee AiyegbusiCentre for Patient-Reported Outcome Research (CPROR), University of Birmingham, Edgbaston, Birmingham, UK.ORCID 0000-0001-9122-8251
Paul CockwellDepartment of Renal Medicine, Queen Elizabeth Hospital, University Hospitals of Birmingham, Edgbaston, Birmingham, UK.ORCID 0000-0003-1975-266X
Philip A KalraDonal O'Donoghue Renal Research Centre, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK.ORCID 0000-0001-7652-1572
Thomas McDonnellDonal O'Donoghue Renal Research Centre, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK.ORCID 0000-0002-2898-4457
Beth LucasCentre for Kidney Research and Innovation, Academic Unit for Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.ORCID 0000-0003-2947-5432
Paul J RoderickSchool of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.
David C WheelerDepartment of Renal Medicine, University College London, London, UK.ORCID 0000-0003-0745-3478
Maarten W TaalCentre for Kidney Research and Innovation, Academic Unit for Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.ORCID 0000-0002-9065-212X
Simon D S FraserSchool of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.ORCID 0000-0002-4172-4406

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiple long-term conditions (MLTC) are common in people with chronic kidney disease (CKD). This study examined the impact of MLTC on mortality, CKD progression, and health-related quality of life (HRQoL) in a referred CKD population.

methodsAdults with non-kidney replacement therapy (KRT)-dependent CKD (stages G1 to G5) were recruited to the prospective NURTuRE-CKD cohort across 16 UK nephrology centres. MLTC was defined as ≥2 conditions (including CKD) and comorbidities categorised into 19 groups. Depression and anxiety were defined using the Hospital Anxiety and Depression Scale, and Cognitive impairment using the Six-item Cognitive Impairment Test. Outcomes were all-cause mortality, CKD progression (eGFR <15 mL/min/1.73m

resultsAll 2996 participants had comorbidities at baseline, and therefore MLTC. Mean age was 62.7 (SD ± 14.7) years, mean eGFR 37.3 mL/min/1.73m

conclusionsGreater comorbidity burden was associated with mortality and worse HRQoL but not CKD progression in this cohort. CKD management should target prevention of additional conditions, prioritise holistic care and focus on MLTC as much as kidney protection.

Indexed as

Kidney Failure, ChronicQuality of LifeRenal Insufficiency, ChronicAgedAnxietyCohort StudiesComorbidityDepressionDisease ProgressionFemaleGlomerular Filtration RateHumansMaleMiddle AgedProspective StudiesUnited KingdomChronic kidney diseaseCKD progressionhealth-related quality of lifemortalitymultimorbiditymultiple long-term conditions

Identifiers

PMID42334309
PMCPMC13292312

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.