Evidence map›Paper›PMID 42334455›Full record

ArticleeLife2026

Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling.

Nevin K Zacharia, Stefanie Kuhns, Niels Boegholm, Anni Christensen, Jiaolong Wang, Narcis A Petriman, Anna Lorentzen, Jindriska L Fialova, Lucie Menguy, Sophie Saunier and 4 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nevin K ZachariaDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0003-2613-2610
Stefanie KuhnsDepartment for Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0002-3065-7818
Niels BoegholmDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Anni ChristensenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Jiaolong WangDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Narcis A PetrimanDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-3189-7530
Anna LorentzenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-4405-935X
Jindriska L FialovaDepartment of Biology, University of Copenhagen, Universitetsparken, Copenhagen Ø, Denmark.
Lucie MenguyLaboratory of Hereditary and Kidney diseases, Institut Imagine, Paris, France.
Sophie SaunierLaboratory of Hereditary and Kidney diseases, Institut Imagine, Paris, France.
Søren Tvorup ChristensenDepartment of Biology, University of Copenhagen, Universitetsparken, Copenhagen Ø, Denmark.ORCID https://orcid.org/0000-0001-5004-304X
Jens S AndersenDepartment for Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Sagar BhogarajuEuropean Molecular Biology Laboratory, Grenoble, France.ORCID https://orcid.org/0000-0001-9998-5927
Esben LorentzenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-6493-7220

Funding

Horizon 2020 Framework Programme 10.3030/861329Novo Nordisk Fonden NNF15OC00114164Novo Nordisk Fonden NNF18SA0032928Novo Nordisk Fonden NNF23OC0085823
6 · The paper itself

Abstract

Intraflagellar transport (IFT) is a fundamental process driving ciliogenesis in most eukaryotic organisms. IFT172, the largest protein of the IFT complex, plays a crucial role in cilium formation, and several disease-causing IFT172 variants have been identified in ciliopathy patients. While IFT172 is tethered to the IFT-B complex via its N-terminal domains, the function of its C-terminal domains has remained elusive. Here, using both human and

Indexed as

CiliaFlagellaSignal TransductionUbiquitinCell LineChlamydomonas reinhardtiiCrystallography, X-RayHumansModels, MolecularProtein BindingProtein DomainsUbiquitinchlamydomonas reinhardtiiciliaciliopathyhumanIFT172intraflagellar transportmolecular biophysicsprotein structurestructural biologyU-box domain

Identifiers

PMID42334455
PMCPMC13290226

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.