Evidence map›Paper›PMID 42334511›Full record

ArticleJournal of computer-aided molecular design2026

Computer-aided design, molecular dynamics simulations and in-vitro inhibitory potential of piperazine bridged bis-thiadiazole benzothioate derivatives against platelet-derived endothelial cell growth factor.

Mujeeb Ul Naeem, Filza Khursheed, Samina Aslam, Yousaf Khan, Waqar Ishaq, Muhammad Akif, Abdul Sattar, Muhammad Faheem, Mohammed B Hawsawi, Wajid Rehman

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Article in Journal of computer-aided molecular design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mujeeb Ul NaeemDepartment of Chemistry, Hazara University Mansehra, Mansehra, Pakistan.
Filza KhursheedDepartment of Zoology, Quaid-I-Azam University Islamabad, Islamabad, 45320, Pakistan.
Samina AslamDepartment of Chemistry, Sardar Bahadur Khan Women University Quetta, Quetta, Pakistan.
Yousaf KhanDepartment of Chemistry, COMSATS University Islamabad, Islamabad, 45550, Pakistan. yousaf7n@gmail.com.
Waqar IshaqDepartment of Telecommunication, Hazara University Mansehra, Mansehra, Pakistan.
Muhammad AkifDepartment of Chemistry, Abbottabad University of Science and Technology, Abbottabad, Pakistan.
Abdul SattarDepartment of Chemistry, COMSATS University Islamabad, Islamabad, 45550, Pakistan.
Muhammad FaheemRiphah Institute of Pharmaceutical Sciences, Riphah International University Islamabad, Islamabad, Pakistan.
Mohammed B HawsawiDepartment of Chemistry, Faculty of Science, Umm Al-Qura University, Al Taif Road, 21955, Makkah, Saudi Arabia.
Wajid RehmanDepartment of Chemistry, Hazara University Mansehra, Mansehra, Pakistan. sono_waj@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulated thymidine phosphorylase (TP) activity has been closely associated with pathological angiogenesis, tumor progression and chronic inflammation. This enzyme underscores as attractive therapeutic target for anticancer intervention. In the present study, we describe the rational design and multi-step synthesis of a focused library of piperazine-linked bis-thiadiazole dibenzothioate (1-6) scaffolds. The chemical structures of all synthesized analogues were spectroscopically confirmed by

Indexed as

Computer-Aided DesignEnzyme InhibitorsPiperazinesThiadiazolesThymidine PhosphorylaseDrug DesignHumansMolecular Docking SimulationMolecular Dynamics SimulationPiperazineStructure-Activity RelationshipEnzyme InhibitorsPiperazinePiperazinesThiadiazolesThymidine PhosphorylaseBis-thiadiazoleDibenzothioateMD simulationsMolecular dockingPiperazineStructure activity relationship (SAR)Thymidine phosphorylase

Identifiers

PMID42334511

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.