ArticleVascular medicine (London, England)2026
Relations of Life's Essential 8 score with arterial and microvascular function: The Jackson Heart Study.
Arko S Dhar, William B Hillegass, Leroy L Cooper, Abu Yusuf Ansari, Ramachandran S Vasan, Gary Mitchell, Ervin R Fox
Abstract read
In one paragraphArticle in Vascular medicine (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors.
William B HillegassUniversity of Mississippi Medical Center, Jackson, MS, USA.
Leroy L CooperVassar College, Poughkeepsie, NY, USA.
Abu Yusuf AnsariJackson Heart Study, Coordinating Center, Jackson, MS, USA.
Ramachandran S VasanUniversity of Texas School of Public Health, San Antonio, TX, USA.
Gary MitchellCardiovascular Engineering, Inc., Needham, MA, USA.
Ervin R FoxUniversity of Mississippi Medical Center, Jackson, MS, USA.
Funding
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GRANGER, JOEY P. · 2016 to 2025
$38.2MCardiac microstructure and the immune-inflammatory response to SARS-CoV-2R01HL131532 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN, LI, DEBIAO · 2016 to 2025
$6.6MMediators of Systemic Inflammation and Heart Failure Risk in the CommunityR01HL143227 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN · 2019 to 2022
$3.3MVentricular-vascular coupling in the elderly: lifecourse determinants, trajectories, and prognostic significanceR01HL142983 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CHENG, SUSAN, MITCHELL, GARY FRANK · 2019 to 2022
$3.2MVascular Stiffness as a Precursor of Hypertension in a Middle-aged CohortR01HL126136 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MITCHELL, GARY FRANK, RAMACHANDRAN, VASAN S · 2015 to 2018
$2.6MAortic Dysfunction, Pulsatile Stress and Target Organ Damage in FraminghamR01HL107385 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MITCHELL, GARY FRANK, RAMACHANDRAN, VASAN S · 2011 to 2014
$2.6MGenome-wide Association Study of Cardiac Structure and FunctionR01HL093328 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2008 to 2011
$2.4MBiomarkers of Metabolic and Vascular Risk in ObesityR01DK080739 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2008 to 2011
$2.1MAortic stiffness, wave reflection, and cerebrovascular flow pulsatility: relations with brain small vessel disease and cognitive function in a middle-aged cohortRF1AG079390 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MITCHELL, GARY FRANK, RAMACHANDRAN, VASAN S · 2023 to 2023
$2.1MVascular hemodynamics and markers of preclinical and subclinical vascular brain injury and dementiaK01HL161494 · NHLBI · VASSAR COLLEGE · PI Leroy Leon Cooper · 2022 to 2026
$728kNHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS K01 HL161494NHLBI NIH HHS R01 HL093328NHLBI NIH HHS R01 HL107385NHLBI NIH HHS R01 HL126136NHLBI NIH HHS R01 HL131532NHLBI NIH HHS R01 HL142983NHLBI NIH HHS R01 HL143227NIA NIH HHS RF1 AG079390NIDDK NIH HHS R01 DK080739NIGMS NIH HHS U54 GM115428NIMHD NIH HHS HHSN268201800013I
6 · The paper itselfAbstract
backgroundThe American Heart Association (AHA) Life's Essential 8 (LE8) provides a means of scoring cardiovascular health but has yet to be correlated with vascular function in an African American cohort.
methodsIn a sample of Jackson Heart Study participants (
resultsA higher LE8 score was associated with lower carotid-femoral pulse wave velocity (β = -0.32; 95% CI: -0.42, -0.21;
conclusionOur findings support the concept that a healthy lifestyle is predictive of better vascular function. Future longitudinal studies are warranted to investigate whether improving LE8 scores leads to improved vascular function.
Indexed as
Black or African AmericanCardiovascular DiseasesMicrocirculationVascular StiffnessAdultAgedCarotid-Femoral Pulse Wave VelocityCross-Sectional StudiesFemaleHealth StatusHeart Disease Risk FactorsHumansMaleMiddle AgedMississippiPredictive Value of Testscardiovascular diseasedisease preventionLife’s Essential 8 (LE8)risk factorsvascular complicationsvascular physiologic testing
Identifiers
PMID42334559
PMCPMC13451589
What Socratic holds
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