Evidence map›Paper›PMID 42334673›Full record

ReviewMedical oncology (Northwood, London, England)2026

Lactate and lactylation in hepatocellular carcinoma: A new frontier in metabolic-epigenetic interactions.

Chen Chen, Yangyang Miao, Songsong Fan, Chengji Tang, Rui Peng, Jiahao Zhang, Jun Cao, Chi Zhang, Dousheng Bai

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical oncology (Northwood, London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chen Chen *Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China.
Yangyang Miao *Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China.
Songsong FanDepartment of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China.
Chengji TangDepartment of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China.
Rui PengDepartment of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China.
Jiahao ZhangDepartment of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China.
Jun CaoDepartment of Hepatobiliary Surgery, Northern Jiangsu People's Hospital, Yangzhou, China.
Chi ZhangDepartment of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China.
Dousheng BaiDepartment of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China. drbaidousheng@yzu.edu.cn.ORCID https://orcid.org/0000-0001-8032-7959

Funding

Health research major project in Jiangsu Province K2023002the "13th Five-Year Plan" Science and Education Strong Health Project Innovation Team of Yangzhou LJRC20181 andYZCXTD201801the Beiing iGanDan Foundation GDXZ-08-19the Cross-Cooperation Special Projects of the NJPH YJCHZ-2021-08the National Natural Science Foundation of China 82373034, 82503422 and 82203716the Postgraduate Research and Practice Innovation Program of Jiangsu Province KYCX23_3617the Provincial-Level Discipline Leader of the NJPH DTRA202214Yangzhou Basic Research Program (Joint Special Project) 2024-3-02, 2025-1-02
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a highly prevalent malignancy with persistently high and increasing mortality rates. Once regarded merely as a metabolic byproduct, lactate is now recognized as a key metabolite in the tumor microenvironment (TME), where it promotes HCC progression through diverse biological functions. Lactylation, a unique post-translational modification, regulates the TME by altering gene expression via the addition of lactate-derived groups to both histone and non-histone proteins. This review summarizes the role of lactate metabolism in the body, examines its effects on various immune cell populations, and highlights recent advances in anti-HCC therapies targeting lactate.

Indexed as

Carcinoma, HepatocellularEpigenesis, GeneticLactic AcidLiver NeoplasmsAnimalsHumansMetabolic ReprogrammingProtein Processing, Post-TranslationalTumor MicroenvironmentLactic AcidLactateLactylationMetabolic reprogrammingTumor microenvironment

Identifiers

PMID42334673

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.