Evidence map›Paper›PMID 42334716›Full record

ArticleCerebellum (London, England)2026

Transitional Life Events in Friedreich Ataxia: Differential Age at Onset Perspectives.

Audrey Iskandar, Maresa Buchholz, Dorota Sarwinska, Stéphanie Borel, Alexandra Durr, Mariana Atencio, Claire Ewenczyk, Anna Heinzmann, Sacha Weber, Rania Hilab and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebellum (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Audrey IskandarGerman Center for Neurodegenerative Diseases, Site Rostock/Greifswald, Patient-reported Outcomes & Health Economics Research, Greifswald, Germany. audrey.iskandar@dzne.de.ORCID https://orcid.org/0009-0007-6400-507X
Maresa BuchholzGerman Center for Neurodegenerative Diseases, Site Rostock/Greifswald, Patient-reported Outcomes & Health Economics Research, Greifswald, Germany.
Dorota SarwinskaGerman Center for Neurodegenerative Diseases, Site Rostock/Greifswald, Patient-reported Outcomes & Health Economics Research, Greifswald, Germany.
Stéphanie BorelSorbonne Université, Paris Brain Institute (ICM - Institut du Cerveau), INSERM, CNRS, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Alexandra DurrSorbonne Université, Paris Brain Institute (ICM - Institut du Cerveau), INSERM, CNRS, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Mariana AtencioSorbonne Université, Paris Brain Institute (ICM - Institut du Cerveau), INSERM, CNRS, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Claire EwenczykSorbonne Université, Paris Brain Institute (ICM - Institut du Cerveau), INSERM, CNRS, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Anna HeinzmannSorbonne Université, Paris Brain Institute (ICM - Institut du Cerveau), INSERM, CNRS, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Sacha WeberSorbonne Université, Paris Brain Institute (ICM - Institut du Cerveau), INSERM, CNRS, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Rania HilabSorbonne Université, Paris Brain Institute (ICM - Institut du Cerveau), INSERM, CNRS, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Feng XieDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Brittany HumphriesDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Thomas KlockgetherGerman Center for Neurodegenerative Diseases, Bonn, Germany.
Marcus Grobe-EinslerGerman Center for Neurodegenerative Diseases, Bonn, Germany.
Vivian MaasGerman Center for Neurodegenerative Diseases, Bonn, Germany.
Katrin FeldmannGerman Center for Neurodegenerative Diseases, Bonn, Germany.
Stéphan RouillonAssociation Française de l'Ataxie de Friedreich, Saint Avé, France.
Andreas NadkeDeutsche Heredo-Ataxie-Gesellschaft, Stuttgart, Germany.
Elin Haf DaviesAparito, a wholly owned subisidiary of Eli Lilly and Company, Ty Dewi Sant, Rhosddu Road, Wrexham, Wales , LL11 1NF, UK.
Martina MinneropDepartment of Neurology, Center for Movement Disorders and Neuromodulation, Medical Faculty, Heinrich-Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.
Friedrich ErdlenbruchDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Almut T BischoffDepartment of Neurology, Ludwig-Maximilians-Universität (LMU), Friedrich-Baur-Institute, Munich, Germany.
Thomas KlopstockDepartment of Neurology, Ludwig-Maximilians-Universität (LMU), Friedrich-Baur-Institute, Munich, Germany.
Zofia FleszarHertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany.
Sylvia BoeschDepartment of Neurology, Center for Rare Movement Disorders Innsbruck, Medical University Innsbruck, Innsbruck, Austria.
Elisabetta IndelicatoDepartment of Neurology, Center for Rare Movement Disorders Innsbruck, Medical University Innsbruck, Innsbruck, Austria.
Jörg B SchulzDepartment of Neurology, RWTH Aachen University, Aachen, Germany.
Kathrin ReetzDepartment of Neurology, RWTH Aachen University, Aachen, Germany.
Bernhard MichalowskyGerman Center for Neurodegenerative Diseases, Site Rostock/Greifswald, Patient-reported Outcomes & Health Economics Research, Greifswald, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Friedreich's ataxia (FA) is a rare, autosomal recessive neurodegenerative disease that primarily affects children and adolescents in their transition to adulthood, which is associated with several adverse life events caused by the disease progression. This article aims to describe life events associated with FA and their impact on patient-reported outcomes in pediatric and adult onsets. A newly adapted Life Events Questionnaire was applied within the PROFA study. The questionnaire captured various disease-, relationship-, and work-related life events. The outcomes were stratified by pediatric and adult-onset groups at subcategory and item levels. Non-parametric tests, along with multivariate regressions with adjustments were employed. A total of 73 patients (44 pediatric-/29 adult-onset) completed the Life Events Questionnaire. Both pediatric and adult onset groups reported a similar number of life events (M

Indexed as

Friedreich AtaxiaLife Change EventsAdolescentAdultAge of OnsetChildFemaleHumansMaleMiddle AgedSurveys and QuestionnairesYoung AdultAdolescence well beingAtaxiaHealth statusLife course perspectiveMovement disorders

Identifiers

PMID42334716
PMCPMC13291036

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.