ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2026
PIV, PNI and HALP score for predicting pathological complete response in breast cancer after neoadjuvant chemotherapy: a systematic review and meta-analysis.
Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study sought to evaluate the associations of prognostic nutritional index (PNI), pan-immune-inflammation value (PIV), and hemoglobin, albumin, lymphocyte, platelet (HALP) score with the pathological complete response (pCR) in breast cancer (BC) patients undergoing neoadjuvant chemotherapy (NAC) and their diagnostic value.
methodsPubMed, Embase, Cochrane Library, and Web of Science were systematically searched to identify eligible studies published up to October 2025. All types of studies examining the associations of PNI, PIV, and HALP with pCR following NAC in patients with BC were retrieved.
resultsA total of 20 studies were included, 7 on PIV, 8 on PNI, and 5 on HALP. The meta-analysis pooling data from univariate regression analyses showed that low PIV (odds ratio [OR] = 1.962, 95% confidence interval [CI] 1.232-3.125, P
conclusionOur study indicates that PIV, PNI, and HALP before neoadjuvant therapy are independently associated with pCR in patients with BC following NAC. However, their capacity as independent diagnostic indicators remains limited. Additional research is warranted to validate our findings.
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