ArticleCNS neuroscience & therapeutics2026
Association of Weight-Adjusted-Waist Index With Brain Health: A 16-Year Population-Based Longitudinal Cohort Study.
Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe long-term association of central obesity with brain structural integrity remains poorly understood. This study aimed to investigate the longitudinal association between cumulative Weight-adjusted-waist Index (WWI) exposure and multi-modal neuroimaging markers of brain health.
methodsThis prospective community-based cohort study included 935 participants from the META-KLS Study. Cumulative WWI was calculated as the time-weighted average over 12 years prior to MRI acquisition. Neuroimaging outcomes included regional gray matter volume, white matter hyperintensity (WMH), and diffusion tensor imaging (DTI) metrics. Generalized linear models, restricted cubic splines, and mediation analyzes were performed.
resultsElevated cumulative WWI was associated with adverse brain structural outcomes, particularly in females. In women, higher WWI was linked to extensive WMH burden (p
conclusionCumulative WWI serves as a potential predictor of adverse brain structural outcomes, particularly manifesting as white matter injury and atrophy in women. Early monitoring of WWI offers a vital window for targeted metabolic interventions to preserve brain structural integrity.
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