Evidence map›Paper›PMID 42334871›Full record

ArticleJCI insight2026

Macrophage-fibroblast signaling networks identified by single-cell RNA sequencing in juvenile systemic sclerosis.

Aneri Shethji, Theresa Hutchins, Anwesha Sanyal, Tianhao Liu, Wei Chen, Kathryn S Torok

Abstract read
In one paragraph

Article in JCI insight, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aneri Shethji
Theresa Hutchins
Anwesha Sanyal
Tianhao Liu
Wei Chen
Kathryn S Torok

Funding

Integrating Spatial and Single-Cell Transcriptomics with Histology to Define Endotypes in Pediatric SclerodermaR01AR086434 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Wei Chen, Kathryn S. Torok · 2025 to 2026
$974k
NIAMS NIH HHS R01 AR086434
6 · The paper itself

Abstract

<style type="text/css">a { text-decoration: none; color: #464feb; } tr th, tr td { border: 1px solid #e6e6e6; } tr th { background-color: #f5f5f5; } </style> Single‑cell analysis of juvenile systemic sclerosis skin reveals altered fibroblast-macrophage interactions that may drive fibrosis and identify pathways relevant to pediatric disease.

Indexed as

FibroblastsMacrophagesScleroderma, SystemicSignal TransductionFibrosisHumansSequence Analysis, RNASingle-Cell AnalysisSingle-Cell Gene Expression AnalysisSkinAutoimmune diseasesDermatologyFibrosisImmunologyRheumatology

Identifiers

PMID42334871
PMCPMC13463615

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.