Macrophages Intracellularly Gelated With Bioactive Hydrogels for Synergistic Neutralization, Eradication, and Osteopromotion in Periodontitis Treatment.

Mingyi Liu, Yunfan Cai, Yan Wang, Xiaoyu Miao, Xufang Liu, Meng Wang, Chuanbin Mao, Yao Zhao, Lina Niu

Abstract read

In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mingyi LiuNational Clinical Research Center For Oral Diseases, State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P. R. China.

Yunfan CaiNational Clinical Research Center For Oral Diseases, State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P. R. China.

Yan WangNational Clinical Research Center For Oral Diseases, State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P. R. China.

Xiaoyu MiaoNational Clinical Research Center For Oral Diseases, State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P. R. China.

Xufang LiuNational Clinical Research Center For Oral Diseases, State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P. R. China.

Meng WangNational Clinical Research Center For Oral Diseases, State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P. R. China.

Chuanbin MaoDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, P. R. China.

Yao ZhaoNational Clinical Research Center For Oral Diseases, State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P. R. China.

Lina NiuNational Clinical Research Center For Oral Diseases, State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, P. R. China.ORCID https://orcid.org/0000-0002-6653-0819

Funding

China Postdoctoral Science Foundation 2024M754272Hong Kong Jockey Club Charities TrustNational Key Research and Development Program of China 2022YFC2405900National Key Research and Development Program of China 2022YFC2405901National Natural Science Foundation of China 82325012National Natural Science Foundation of China U25A2097Natural Science Basic Research Program of Shaanxi Province 2024JC-YBQN-0804

6 · The paper itself

Abstract

Conventional periodontitis therapy is limited by the lack of an all-in-one material with the desired functions of toxin neutralization, pathogen eradication, and osteopromotion. Exploiting the innate capacity of macrophages to recognize and neutralize pathological stimuli, this study develops novel engineered macrophage-based materials: phytate/Zn

Indexed as

HydrogelsMacrophagesPeriodontitisAnimalsMiceOsteogenesisPhytic AcidRAW 264.7 CellsHydrogelsPhytic Acidgelated macrophagesmineralizationneutralizationosteogenesisperiodontitis

Identifiers

PMID42335290

DOI10.1002/adma.202519288

PMCPMC13410628

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.