Evidence map›Paper›PMID 42335846›Full record

ArticleRedox biology2026

Mitochondrial OXPHOS integrates immunometabolic cascade for bone regeneration via coupled ATP production and ROS homeostasis.

Jingrong Chen, Ping He, Jiayi Gu, Jingqi Wu, Yuxiao Liu, Wei Lei, Tong-Chuan He, Liwen Zheng, Joost D de Bruijn, Huipin Yuan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jingrong ChenThe Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, PR China; Chongqing Key Laboratory of Oral Diseases, Chongqing, 401147, PR China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147, PR China; Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing, 401147, PR China.
Ping HeThe Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, PR China; Chongqing Key Laboratory of Oral Diseases, Chongqing, 401147, PR China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147, PR China; Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing, 401147, PR China.
Jiayi GuThe Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, PR China; Chongqing Key Laboratory of Oral Diseases, Chongqing, 401147, PR China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147, PR China; Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing, 401147, PR China.
Jingqi WuThe Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, PR China; Chongqing Key Laboratory of Oral Diseases, Chongqing, 401147, PR China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147, PR China; Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing, 401147, PR China.
Yuxiao LiuThe Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, PR China; Chongqing Key Laboratory of Oral Diseases, Chongqing, 401147, PR China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147, PR China; Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing, 401147, PR China.
Wei LeiThe Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, PR China; Chongqing Key Laboratory of Oral Diseases, Chongqing, 401147, PR China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147, PR China; Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing, 401147, PR China.
Tong-Chuan HeMolecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, 60637, USA.
Liwen ZhengThe Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, PR China; Chongqing Key Laboratory of Oral Diseases, Chongqing, 401147, PR China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147, PR China; Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing, 401147, PR China.
Joost D de BruijnKuros Biosciences BV, Prof. Bronkhorstlaan 10, Bilthoven, 3723 MB, the Netherlands.
Huipin YuanKuros Biosciences BV, Prof. Bronkhorstlaan 10, Bilthoven, 3723 MB, the Netherlands; Huipin Yuan's Lab, Chengdu, 610000, PR China. Electronic address: huipin.yuan@kurosbio.com.
Hongmei ZhangThe Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, PR China; Chongqing Key Laboratory of Oral Diseases, Chongqing, 401147, PR China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147, PR China; Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing, 401147, PR China. Electronic address: hmzhang@hospital.cqmu.edu.cn.
Mingzheng LiThe Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, PR China; Chongqing Key Laboratory of Oral Diseases, Chongqing, 401147, PR China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147, PR China; Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing, 401147, PR China. Electronic address: mingzhengli369@hospital.cqmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoinductive calcium phosphate ceramics (CaPs) hold great promise for bone repair, yet the metabolic principles governing their efficacy are poorly defined. Here, we identify mitochondrial oxidative phosphorylation (OXPHOS) as an early and indispensable pathway activated specifically by an osteoinductive tricalcium phosphate (TCPS) in material-induced bone formation. Our findings demonstrate that OXPHOS critically governs the M2 macrophage-osteoclast axis for bone formation by regulating both cellular energy supply and reactive oxygen species (ROS) homeostasis. Disrupting either function-by inhibiting OXPHOS (reducing ATP production) or by disrupting ROS balance (including ROS scavenging or accumulation)-uncouples this metabolic-immunological cascade and abrogates bone formation. Our work establishes mitochondrial OXPHOS as a central metabolic hub that integrates bioenergetics with ROS balance to orchestrate material-induced bone formation via M2 macrophage polarization-osteoclastogenesis axis. Consequently, these insights provide a rational basis for therapeutic modulation of the immunometabolic cascade in bone regeneration, via strategies designed to co-activate OXPHOS and fine-tune ROS dynamics.

Indexed as

Bone RegenerationCalcium PhosphatesEnergy MetabolismOsteogenesisOxidative PhosphorylationProstheses and ImplantsAnimalsAnimals, Outbred StrainsHomeostasisMaleMiceMitochondriaOsteoclastsOxidation-ReductionReactive Oxygen Speciesbeta-tricalcium phosphateCalcium PhosphatesReactive Oxygen Speciestricalcium phosphateMacrophage polarizationOsteoclastOsteoinductive materialsOxidative phosphorylationReactive oxygen species

Identifiers

PMID42335846
PMCPMC13316236

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.