Evidence mapPaperPMID 42335932Full record

ReviewGigaScience2026

From the brain cell atlas to precision neurology: a review of the application of AI-driven multi-omics in brain science.

Youzhe He, Yanrong Wei, Jingxi Zhi, Chunyu Huang, Lei Han, Shiping Liu, Lifang Wang

Abstract readReview
In one paragraph

Review in GigaScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Youzhe HeCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.ORCID 0009-0004-9534-0303
Yanrong WeiCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.ORCID 0009-0004-0075-2605
Jingxi ZhiBGI Research, Hangzhou 310030, China.
Chunyu HuangCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Lei HanBGI Research, Shenzhen 518083, China.ORCID 0000-0002-7535-7915
Shiping LiuCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.ORCID 0000-0003-0019-619X
Lifang WangBGI Research, Hangzhou 310030, China.ORCID 0000-0002-6235-3069

Funding

Key Program of the National Natural Science Foundation of China 32530027National Key Research and Development (R&D) Program of China 2021YFA0805100National Science and Technology Innovation 2030 Major Program 2021ZD0204400
6 · The paper itself

Abstract

Recent advances in multi-omics technologies have catalyzed the construction of comprehensive brain cell atlases, providing essential data foundations for artificial intelligence (AI)-driven analyses in precision neurology. This review systematically examines how the integration of AI with single-cell multi-omics and spatial multi-omics advances the resolution in deciphering brain cellular architecture across health and disease states. Through systematic evaluation of multi-omics datasets from neurodegenerative, psychiatric, and neurodevelopmental disorders, we demonstrate how AI facilitates disease subtype stratification, biomarker discovery, and therapeutic target identification. We critically address translational challenges, including data standardization, model interpretability, and regulatory frameworks for clinical implementation. Notably, the establishment of the International Consortium for Primate Brain Mapping in 2025 exemplifies ongoing global collaborative efforts toward systematic multi-omics atlas construction across species and disease states. This synthesis underscores a paradigm shift toward AI-enabled, mechanism-driven analyses, ultimately positioning precision neurology as a realizable framework for individualized diagnosis and targeted interventions in complex brain disorders. .

Indexed as

Artificial IntelligenceBrainBrain DiseasesNeurologyPrecision MedicineAnimalsHumansMultiomicsartificial intelligenceBrain cell atlasmulti-omicsprecision neurology

Identifiers

PMID42335932
PMCPMC13354932

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.