Observational studyRMD open2026
Site-specific articular responses to b/tsDMARDs in rheumatoid arthritis: a longitudinal observational study from the Swiss Clinical Quality Management Registry.
Observational study in RMD open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
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Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWhether treatment response differs across affected joints in rheumatoid arthritis (RA) remains unclear. We sought to determine whether responses to tumour necrosis factor inhibitors (TNFi) and other biologic/targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) vary across individual joints in a large cohort of patients with RA.
methodsPatients with RA from the Swiss Clinical Quality Management in Rheumatic Diseases registry with ≥1 swollen joint at treatment initiation of a b/tsDMARD (abatacept, interleukin-6 receptor inhibitor (IL-6Ri), Janus kinase inhibitor (JAKi), rituximab and TNFi) were included. Time to resolution of swollen joints was evaluated over a 2-year follow-up using mixed effects models accounting for interval-censored data. The analyses compared the speed of improvement of individual joints within the 28-joint count to that of the wrist. The primary analysis focused on bio-naïve patients initiating TNFi treatment, while secondary analyses included all b/tsDMARD classes, irrespective of treatment line.
resultsA TNFi was initiated in 598 patients with ≥1 swollen joint, while 1942 patients with ≥1 swollen joint started a b/tsDMARD (abatacept: 242, IL-6Ri: 317, JAKi: 333, rituximab: 176, TNFi: 874). Compared with the wrist, all joints demonstrated higher rates of resolution, except for the second and third metacarpophalangeal (MCP2/3) joints and, in some analyses, the knee. This pattern of joint-specific response was consistent across all b/tsDMARDs.
conclusionsThe wrist, MCP2 and MCP3 joints resolve more slowly than other joints following treatment with b/tsDMARDs, indicating that a longer evaluation period of treatment response and/or bridging intra-articular steroid injections may be required when these joints are affected.
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