Evidence map›Paper›PMID 42336833›Full record

ArticleNature communications2026

Context-dependent regulation of IgH V(D)J recombination by cohesin-STAG1 and cohesin-STAG2.

Fujung Chang, Brigette Berke-Reynolds, Xinrui Yu, Emma L Bush, Jorge A Colón-Rosado, Liangliang Sun, Jianrong Wang, Yu Zhang

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fujung ChangDepartment of Microbiology, Genetics and Immunology, Michigan State University, East Lansing, MI, USA.
Brigette Berke-ReynoldsDepartment of Microbiology, Genetics and Immunology, Michigan State University, East Lansing, MI, USA.
Xinrui YuDepartment of Computational Mathematics, Science and Engineering, Michigan State University, East Lansing, MI, USA.ORCID 0009-0008-7391-6489
Emma L BushDepartment of Microbiology, Genetics and Immunology, Michigan State University, East Lansing, MI, USA.
Jorge A Colón-RosadoDepartment of Chemistry, Michigan State University, East Lansing, MI, USA.ORCID 0009-0007-5615-3806
Liangliang SunDepartment of Chemistry, Michigan State University, East Lansing, MI, USA.ORCID 0000-0001-8939-5042
Jianrong WangDepartment of Computational Mathematics, Science and Engineering, Michigan State University, East Lansing, MI, USA. wangj164@msu.edu.ORCID 0000-0002-9290-4888
Yu ZhangDepartment of Microbiology, Genetics and Immunology, Michigan State University, East Lansing, MI, USA. yzhang22@msu.edu.ORCID 0000-0002-1126-770X

Funding

Chromatin looping directed RAG targeting during V(D)J recombinationR01AI155775 · NIAID · WESTERN MICHIGAN UNIV SCHOOL OF MEDICINE · PI ZHANG, YU · 2021 to 2025
$1.9M
Advancing top-down proteomics with capillary electrophoresis-mass spectrometryR35GM153479 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Liangliang Sun · 2024 to 2026
$1.4M
Michigan State University (Michigan State University Spartans) Strategic Partnership GrantNSF | BIO | Division of Biological Infrastructure (DBI) DBI-1942143NSF | Directorate for Mathematical & Physical Sciences | Division of Mathematical Sciences (DMS) DMS-2152011United States Department of Agriculture | Agricultural Research Service (USDA Agricultural Research Service) 2022-70410-38419U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI155775U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM153479
6 · The paper itself

Abstract

Cohesin-mediated loop extrusion is central to IgH V(D)J recombination in early developing B cells, driving D-to-J

Indexed as

Cell Cycle ProteinsChromosomal Proteins, Non-HistoneImmunoglobulin Heavy ChainsV(D)J RecombinationAcetyltransferasesAnimalsB-LymphocytesCCCTC-Binding FactorChromatinCohesinsMiceNuclear ProteinsPrecursor Cells, B-LymphoidProteinsAcetyltransferasesCCCTC-Binding FactorCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneCohesinsCtcf protein, mouseImmunoglobulin Heavy ChainsNuclear ProteinsProteinsWAPL protein, mouse

Identifiers

PMID42336833
PMCPMC13291235

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.