Evidence map›Paper›PMID 42336899›Full record

ArticleScientific reports2026

Chronic kidney disease and stromal cell-derived factor 1α peptide-functionalization impact on polycarbonate-bisurea based in situ tissue-engineered vascular graft dynamics.

M M Krebber, P J Besseling, R C H Driessen, A M Lichauco, W Szymczyk, S H M Söntjens, H M Janssen, M Teraa, J O Fledderus, A I P M Smits and 3 more

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

M M Krebber *Department of Nephrology and Hypertension, University Medical Center Utrecht, P.O. Box 8599, 3508 GA, Utrecht, The Netherlands.
P J Besseling *Department of Nephrology and Hypertension, University Medical Center Utrecht, P.O. Box 8599, 3508 GA, Utrecht, The Netherlands.
R C H DriessenDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
A M LichaucoDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
W SzymczykDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
S H M SöntjensSyMO-Chem BV, Eindhoven, The Netherlands.
H M JanssenSyMO-Chem BV, Eindhoven, The Netherlands.
M TeraaDepartment of Nephrology and Hypertension, University Medical Center Utrecht, P.O. Box 8599, 3508 GA, Utrecht, The Netherlands.
J O FledderusDepartment of Nephrology and Hypertension, University Medical Center Utrecht, P.O. Box 8599, 3508 GA, Utrecht, The Netherlands.
A I P M SmitsDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
P Y W DankersDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
C V C BoutenDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
M C VerhaarDepartment of Nephrology and Hypertension, University Medical Center Utrecht, P.O. Box 8599, 3508 GA, Utrecht, The Netherlands. M.C.Verhaar@UMCUtrecht.nl.

Funding

Netherlands Organization for Scientific Research Gravitation Program "Materials Driven Regeneration", No. 024.003.013the Netherlands CardioVascular Research Initiative: The Dutch Heart Foundation CVON2012-01, 1Valve
6 · The paper itself

Abstract

Bioresorbable grafts offer promise for in situ tissue engineered blood vessels (TEBVs), yet balancing graft degradation and neo-tissue formation remains challenging. Chronic kidney disease (CKD) may affect this balance, potentially limiting TEBV effectiveness in CKD-patients. To investigate this, we implanted electrospun, polycarbonate-bisurea (PC-BU) TEBVs in healthy (sham) and 5/6

Indexed as

Blood Vessel ProsthesisChemokine CXCL12Polycarboxylate CementRenal Insufficiency, ChronicTissue EngineeringUreaAnimalsMaleRatsChemokine CXCL12polycarbonatePolycarboxylate CementUreaBiodegradabilityBlood vesselsChronic kidney diseaseFunctionalizationIn situ tissue engineeringSupramolecular materials

Identifiers

PMID42336899
PMCPMC13575257

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.