Evidence map›Paper›PMID 42336934›Full record

ArticleScientific reports2026

Chemical composition and oral sub-chronic safety of Algerian propolis with in silico targeting of Keap1-Nrf2 and mitochondrial proteins.

Widad Kebsa, Hassiba Rouibah, Samia Belahcene, Tomilola Victor Akingbade, Haruna Isiyaku Umar, Mesbah Lahouel, Rana M Aldossari, Vidya Devanathadesikan Seshadri, Sadaf Farooqui, Sherouk Hussein Sweilam

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Widad KebsaLaboratory of Molecular Toxicology, Department of Cellular and Molecular Biology, Faculty of Nature and Life Sciences, University of Jijel, 18000, Jijel, Algeria. w.kebsa@univ-jijel.dz.
Hassiba RouibahLaboratory of Molecular Toxicology, Department of Cellular and Molecular Biology, Faculty of Nature and Life Sciences, University of Jijel, 18000, Jijel, Algeria.
Samia BelahceneLaboratory of Biotechnology, Environment and Health, Faculty of Nature and Life Sciences, University of Jijel, 18000, Jijel, Algeria.
Tomilola Victor AkingbadeComputer-Aided Therapeutic Discovery and Design Platform, Federal University of Technology, PMB 704 Akure, Gaga, 340110, Nigeria.
Haruna Isiyaku UmarComputer-Aided Therapeutic Discovery and Design Platform, Federal University of Technology, PMB 704 Akure, Gaga, 340110, Nigeria.
Mesbah LahouelLaboratory of Molecular Toxicology, Department of Cellular and Molecular Biology, Faculty of Nature and Life Sciences, University of Jijel, 18000, Jijel, Algeria.
Rana M AldossariDepartment of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam Bin Abdelaziz University, Kingdom of Saudi Arabia, Al Kharj, Saudi Arabia.
Vidya Devanathadesikan SeshadriDepartment of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam Bin Abdelaziz University, Kingdom of Saudi Arabia, Al Kharj, Saudi Arabia.
Sadaf FarooquiDepartment of Clinical Pharmacy, Prince Sattam Bin Abdulaziz University, Kingdom of Saudi Arabia, Al-Kharj, Saudi Arabia.
Sherouk Hussein SweilamDepartment of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia. s.sweilam@psau.edu.sa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Algerian propolis has shown promising biological activities, but data on its safety profile remain limited. This study investigated the phytochemical composition and antioxidant activity of an ethanolic extract of Algerian propolis (EEP), as well as its sub-chronic toxicity at an oral dose of 100 mg/kg/day for 30 days in rats. EEP exhibited high levels of total polyphenols and flavonoids with low contents of hydrolysable and condensed tannins. GC-MS analysis identified naringenin (17.48%), pinocembrin (15.62%), 3-(acetylmethyl)-β-pinene (8.23%), 3(Z)-cembrene A (6.36%) and totarol (5.78%) as major constituents. In vitro, EEP effectively scavenged superoxide anion (O

Indexed as

Kelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2PropolisAdministration, OralAlgeriaAnimalsAntioxidantsMaleMitochondriaMolecular Docking SimulationRatsAntioxidantsKEAP1 protein, ratKelch-Like ECH-Associated Protein 1Nfe2l2 protein, ratNF-E2-Related Factor 2Propolisbc1 complexCyclophilin DGC-MS analysisKeap1-Nrf2PropolisSub-chronic toxicity

Identifiers

PMID42336934
PMCPMC13578332

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.