ArticleScientific reports2026
A LAMP-based assay for rapid detection of human scabies using clinical skin scraping specimens.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Scabies, a common parasitic skin disease caused by Sarcoptes scabiei var. hominis, presents diagnostic challenges because of its diverse clinical manifestations and the limited sensitivity of traditional methods, such as skin scraping. Here, we developed a loop-mediated isothermal amplification (LAMP) assay targeting two S. scabiei-specific genes, Sarcoptes scabiei allergen Sar s 3 (Sars3) and Internal Transcribed Spacer 2 (ITS2). To enhance operational simplicity, a direct lysis protocol was employed, enabling rapid template DNA acquisition from skin scraping specimens without conventional DNA extraction. Primer sets were optimized for amplification speed and specificity; reaction temperatures were determined to be 67 °C for Sars3 and 61 °C for ITS2. The assay achieved detection within 35 min, with limits of detection of 10
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