Evidence mapPaperPMID 42337147Full record

ReviewCurrent microbiology2026

Clinical Manifestations and Immunological Impacts in Co-Infections and Sequential Infections of SARS-CoV-2 and Arboviruses.

Jalviana Lansayan, Kim-Ling Chin, Sazaly AbuBakar, Nurhafiza Zainal

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jalviana LansayanTropical Infectious Diseases Research and Education Centre, Universiti Malaya, Kuala Lumpur, 50603, Malaysia.
Kim-Ling ChinDepartment of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, 50603, Malaysia. kimling@um.edu.my.
Sazaly AbuBakarTropical Infectious Diseases Research and Education Centre, Universiti Malaya, Kuala Lumpur, 50603, Malaysia.
Nurhafiza ZainalDepartment of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, 50603, Malaysia. nurhafizazainal@um.edu.my.

Funding

Ministry of Higher Education, Malaysia MO002D-2021
6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and arboviruses represent major global public health threats, each with distinct epidemiological and pathogenic profiles that often overlap in endemic regions. Reports of co-infection and cross-reactivity between these viruses highlight the need for deeper understanding of their interactions. Co-infections pose diagnostic challenges due to overlapping clinical symptoms and immune modulation, which may exacerbate disease severity. Moreover, antibodies generated from prior virus infections may influence the outcome of subsequent infections through mechanisms such as cross-reactivity and antibody-dependent enhancement (ADE). This review summarises current knowledge on the clinical manifestations and immunological consequences of co- and subsequent infections involving SARS-CoV-2 and arboviruses. Emphasis is placed on underlying pathophysiological mechanisms, including cross-reactivity and ADE, that shape host immune responses. Understanding these interactions is essential for improving diagnostic accuracy and guiding public health strategies to mitigate the risks associated with co-infections and sequential viral infections.

Indexed as

Arbovirus InfectionsCoinfectionCOVID-19Antibody-Dependent EnhancementArbovirusesCross ReactionsHumansPandemicsSARS-CoV-2

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.