Evidence map›Paper›PMID 42337155›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026

Determining the feasibility of self-administered relaxing acupressure for fatigue among adolescent and young adult cancer survivors.

Robert Knoerl, John Jardine, Rashmi Chugh, Leslie A Fecher, N Lynn Henry, Madeline Joquico, Yasmin Karimi, Robert Ploutz-Snyder, Sofia Taylor, Emily Walling and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06442891 (A Pilot Study of Self-Administered Acupressure for Fatigue Among Adolescent and Young Adult), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06442891 nacompletednot on this map

A Pilot Study of Self-Administered Acupressure for Fatigue Among Adolescent and Young Adult (AYA) Cancer Survivors

TypeinterventionalSponsorUniversity of Michigan Rogel Cancer CenterRan2024 to 2025Enrolled42ConditionsHematopoietic and Lymphatic System Neoplasm, Malignant Solid NeoplasmArmsAcupressure Therapy, Internet-Based Intervention, Interview, Questionnaire Administration
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Robert KnoerlDepartment of Health Behavior and Clinical Sciences, University of Michigan School of Nursing, 400 North Ingalls St, Ann Arbor, MI, 48109, USA. rjknoerl@med.umich.edu.ORCID http://orcid.org/0000-0002-6996-5068
John JardineApplied Biostatistics Laboratory, University of Michigan School of Nursing, Ann Arbor, MI, 48109, USA.
Rashmi ChughDivision of Hematology/Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Leslie A FecherDivision of Hematology/Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
N Lynn HenryDivision of Hematology/Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Madeline JoquicoDepartment of Health Behavior and Clinical Sciences, University of Michigan School of Nursing, Ann Arbor, MI, 48109, USA.
Yasmin KarimiDivision of Hematology/Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Robert Ploutz-SnyderCollege of Nursing, Wayne State University, Detroit, MI, 48202, USA.
Sofia TaylorDepartment of Health Behavior and Clinical Sciences, University of Michigan School of Nursing, Ann Arbor, MI, 48109, USA.
Emily WallingDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Suzanna ZickDepartment of Family Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the feasibility and acceptability of a 6-week, self-administered relaxing acupressure intervention in AYAs with clinically significant cancer-related fatigue (CRF) and explore its preliminary impact on CRF severity compared to sham acupressure.

methodsIn this pilot randomized controlled trial, 42 post-treatment AYA cancer survivors (PROMIS Fatigue 4a T-score ≥ 55) at least 3 months post-treatment were recruited from a comprehensive cancer center and social media and randomized 2:1 to relaxing or sham acupressure. Participants stimulated five acupoints daily for 27 min over 6 weeks. PROMIS measures were completed at baseline, 6 weeks, and 10 weeks. Feasibility outcomes included recruitment, retention, fidelity, adherence, and acceptability. Mixed effects linear regression evaluated changes in CRF over time.

resultsRecruitment averaged 3.5 participants/month. Outcome completion was ≥ 69% at baseline, week 6, and week 10. Adherence was variable as 38% of participants completed an average of three or more sessions per week. Fatigue severity significantly decreased from baseline to 6 weeks (control - 8.07, p = 0.0015; acupressure - 10.12, p < 0.0001) and remained improved at 10 weeks in both groups, with no significant between-group differences.

conclusionsSelf-administered acupressure is feasible for AYA cancer survivors. Clinically meaningful fatigue reductions occurred in both groups; however, variable adherence and no between-group differences underscore the need to optimize dose and adherence strategies in a future trial. IMPLICATIONS FOR CANCER SURVIVORS: Acupressure is a low-cost, self-directed strategy that may help manage CRF. Future research should work to identify the optimal dose and adherence supports to maximize benefit for AYA survivors.

trial registrationClinicalTrials.gov Identifier: NCT06442891, registered June 4, 2024.

Indexed as

AcupressureFatigueNeoplasmsAdolescentAdultCancer SurvivorsFeasibility StudiesFemaleHumansMalePatient CompliancePilot ProjectsSelf AdministrationSelf CareSeverity of Illness IndexYoung AdultAcupressureAdolescentFatigueRandomized controlled trialSurveys and questionnairesYoung adult

Identifiers

PMID42337155
PMCPMC13290998

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.