Evidence map›Paper›PMID 42337262›Full record

ArticleNature communications2026

Dual Photoredox/Cobalt Catalysis Enabled Regiospecific Markovnikov Hydroboration of Unactivated Mono-, Di-, and Trisubstituted Alkenes.

Xin-Yu Xu, Hong-Chao Liu, Yiliang Chen, Tao Zhang, Heng Cai, Qi Wang, Li Rao, Siyuan Tang, Yong-Min Liang, Xinya Han

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Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xin-Yu Xu *School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, P. R. China.
Hong-Chao Liu *Key Laboratory of Micro-Nano Powder and Advanced Energy Materials of Anhui Higher Education Institutes, School of Materials and Environmental Engineering, Chizhou University, Chizhou, 247000, Anhui, P. R. China. liuhc2022@126.com.ORCID http://orcid.org/0009-0009-4968-2149
Yiliang ChenSchool of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, P. R. China.
Tao ZhangSchool of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, P. R. China.
Heng CaiKey Laboratory of Micro-Nano Powder and Advanced Energy Materials of Anhui Higher Education Institutes, School of Materials and Environmental Engineering, Chizhou University, Chizhou, 247000, Anhui, P. R. China.
Qi WangSchool of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, P. R. China.
Li RaoEngineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079, Hubei, P. R. China. raoli@ccnu.edu.cn.ORCID http://orcid.org/0000-0002-0780-6504
Siyuan TangSchool of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, P. R. China.
Yong-Min LiangState Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, Gansu, P.R. China. liangym@lzu.edu.cn.ORCID http://orcid.org/0000-0001-8280-8211
Xinya HanSchool of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, 243002, Anhui, P. R. China. xinyahan@ahut.edu.cn.ORCID http://orcid.org/0000-0003-4439-9132

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydroboration of alkenes constitutes an important synthetic tool to assemble valuable alkylboron molecules. Although various protocols have been developed, the regiospecific Markovnikov reactions of unactivated alkenes, in particular for trisubstituted ones, remain formidable challenges. Here, we report a general method for the Markovnikov hydroboration of unactivated mono-, di- and trisubstituted alkenes enabled by dual photoredox/cobalt catalysis. The reaction proceeds via a photoinduced metal-hydride hydrogen atom transfer of unactivated alkenes followed by a versatile radical borylation process. This strategy is characterized by its Markovnikov selectivity, mild reaction conditions, high catalytic efficiency and broad substrate scope. This method demonstrates a reaction pattern that achieves the hydroboration of unactivated alkenes through the combination of reductive metal-hydride hydrogen atom transfer and radical borylation. Moreover, this catalytic system can also be applied to complex substrates derived from natural products. The mechanism presented is supported by control experiments and density functional theory calculations.

Identifiers

PMID42337262
PMCPMC13442844

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.