ArticleBMC cancer2026
The clinical value of the combined detection of circulating low ⁃ density neutrophils and inflammatory markers in breast cancer with lymph node metastasis.
Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Explainable AI-Derived Spatial Pathological Features of Tumor, Necrosis, and Lymphocytes Identify Key Histological Signatures for Residual Cancer Burden Assessment in Breast Cancer.Diagnostics (Basel, Switzerland) · 2026Article
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5 authors.
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Abstract
backgroundBreast cancer (BC) is the most prevalent cancer in women globally, with axillary lymph node metastasis (LNM) and distant metastasis being key prognostic factors linked to survival. Circulating low-density neutrophils (LDNs) in cancer patients are associated with tumor-supportive role. This study assessed the clinical relevance of combining circulating LDNs with hematological indicators in BC patients with LNM.
methodsPeripheral blood samples from 184 BC patients were analyzed using flow cytometry to measure the LDNs levels. Lasso logistic regression was used for variable selection, and univariate and multivariate logistic regression identified independent risk factors. A predictive nomogram was developed and validated with an external cohort.
resultsLDNs were elevated in BC patients, especially those with LNM. Seven variables-LDNs, CEA, CA153, PLR, SIRI, NMLR, and NHR-were identified for further analysis. Multivariate logistic regression identified five of these as independent risk factors for LNM: LDNs (OR = 2.307, P = 0.032), CEA (OR = 4.027, P < 0.001), CA153 (OR = 2.440, P = 0.016), PLR (OR = 2.563, P = 0.014), and SIRI (OR = 4.617, P = 0.003). The nomogram model based on these factors demonstrated good predictive performance with an optimism-corrected C-statistic of 0.780, consistent in the external validation set (AUC = 0.762). The calibration curve confirmed good clinical applicability.
conclusionThis study suggests circulating LDNs levels may be potential biomarkers for BC progression, and a nomogram combing LDNs with other hematological indicators shows potential for identifying patients with LNM.
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