Evidence map›Paper›PMID 42338586›Full record

ArticleFrontiers in immunology2026

Differentiation defects reposition sebaceous glands as inflammatory instigators in the early pathogenesis of hidradenitis suppurativa.

Xiang Chen, Jiaqi Li, Yibo Feng, Zhanyan Pan, Qiong Wu, Xinyi Xu, Qian Zhao, Tingting Hu, Guangjie Chen, Christos C Zouboulis and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiang ChenDepartment of Dermatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Jiaqi LiDepartment of Dermatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yibo FengDepartment of Dermatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhanyan PanDepartment of Dermatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Qiong WuDepartment of Dermatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Xinyi XuDepartment of Dermatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Qian ZhaoDepartment of Dermatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Tingting HuDepartment of Dermatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Guangjie ChenDepartment of Immunology and Microbiology, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Christos C ZouboulisDepartment of Dermatology, Venereology and Immunology, Universitaetsklinikum Ruppin-Brandenburg, Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg, Neuruppin, Germany.
Xiaohui MoDepartment of Dermatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Qiang JuDepartment of Dermatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The role of sebaceous glands (SGs) in the early pathogenesis of hidradenitis suppurativa (HS) remains undefined, with an unclear causal relationship to inflammatory sequelae. The aim of this study is to determine whether SG aberrations constitute a primary pathogenic driver in early HS and elucidate the underlying mechanisms. Methods: We employed histology, single-cell RNA sequencing, and Results: SG size was significantly reduced in both NLS (47.26% of HC area, Conclusions: SG dysfunction, initiated by tight junction disruption and CLDN1 deficiency, is a primary event in early HS. This leads to aberrant sebocyte differentiation, inflammatory amplification, and sebum metabolite LPC-mediated crosstalk with keratinocytes. Our findings position SG-derived LPC as a potential novel biomarker and therapeutic target in HS pathogenesis.

Indexed as

Cell DifferentiationHidradenitis SuppurativaSebaceous GlandsAdultCell LineFemaleHumansInflammationMaleTight JunctionsHidradenitis suppurativalysophosphatidylcholinesebaceous glandsebumtight junction

Identifiers

PMID42338586
PMCPMC13283874

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.