Evidence map›Paper›PMID 42338684›Full record

ArticleAccess microbiology2026

Investigating the lasting effects of SARS-CoV-2 infection and the lung microbiome: no persistent microbial alterations in recovered COVID-19 patients with persistent radiological or respiratory abnormalities.

Nancy M Y Teng, Bavithra Vijayakumar, David J F Smith, James Tonkin, Christopher M Orton, Justin L Garner, James A Harker, Clare M Lloyd, Philip L Molyneaux, Pallav L Shah

Abstract read
In one paragraph

Article in Access microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nancy M Y Teng *National Heart and Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0003-0008-8404
Bavithra Vijayakumar *National Heart and Lung Institute, Imperial College London, London, UK.
David J F SmithNational Heart and Lung Institute, Imperial College London, London, UK.
James TonkinChelsea and Westminster Hospital, London, UK.
Christopher M OrtonNational Heart and Lung Institute, Imperial College London, London, UK.
Justin L GarnerChelsea and Westminster Hospital, London, UK.
James A HarkerNational Heart and Lung Institute, Imperial College London, London, UK.
Clare M LloydNational Heart and Lung Institute, Imperial College London, London, UK.
Philip L MolyneauxNational Heart and Lung Institute, Imperial College London, London, UK.
Pallav L ShahNational Heart and Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-9052-4638

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was a global pandemic where infected individuals experienced mild or severe disease. Unfortunately, some patients who experienced severe disease also had lasting abnormalities. The lung microbiome of 38 adult coronavirus disease 2019 (COVID-19) patients with persistent respiratory symptoms and/or radiological abnormalities was analysed. The aim was to investigate whether the lasting radiological abnormalities reported in this cohort were associated with an altered airway. Thirty-six bronchoalveolar lavage fluid samples from patients underwent 16S rRNA gene amplicon sequencing and were compared to 28 non-fibrotic control samples from a previously published study. COVID-19 patients had statistically significantly greater number of genera but at uneven abundances, though not statistically significant compared to non-fibrotic controls. Permutational ANOVA (PERMANOVA) suggested that COVID-19 can influence the lung microbiome composition after accounting for multivariate dispersion. Further analysis showed differences in the relative abundances of

Indexed as

16S rRNA gene amplicon sequencingairway microbiotacoronavirus disease 2019 (COVID-19)microbiotapulmonary fibrosis

Identifiers

PMID42338684
PMCPMC13286284

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.