ArticleFrontiers in cardiovascular medicine2026
Blood pressure-stratified associations of the atherogenic index of plasma with all-cause mortality: a 10-year rural cohort study in China.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Although the role of AIP in predicting cardiovascular disease has been recognized, its association with all-cause mortality in different blood pressure status populations remains unclear. This study aims to investigate the predictive ability of the Atherogenic Index of Plasma (AIP) and its modified indices for all-cause mortality in rural low-income populations with different blood pressure statuses and compare them with the Triglyceride-Glucose (TyG) index. Methods: A total of 3,924 rural low-income participants were included in this study. Sociodemographic variables, lifestyle habits, anthropometric measurements, and biochemical markers were systematically recorded. Cox regression and restricted cubic spline (RCS) analyses were used to explore the linear and non-linear associations between TyG and AIP and their modified indices (TyG-BMI, TyG-WHtR, TyG-WC, TyG-WWI, AIP-BMI, AIP-WHtR, AIP-WC, AIP-WWI) and all-cause mortality. Kaplan-Meier survival curves were plotted. Time-dependent receiver operating characteristic (ROC) curves were constructed separately in the hypertensive and non-hypertensive groups to evaluate and compare the predictive ability of TyG and AIP and related indices for all-cause mortality. Additionally, subgroup analyses were performed based on age, gender, and blood glucose status, and mediation analyses were conducted for fasting blood glucose and LDL. Results: During a median follow-up of 8.82 years, 1,024 cases of all-cause mortality were recorded. After adjusting for confounders, in the hypertensive group, TyG and AIP and their modified indices were significantly negatively associated with all-cause mortality (all Conclusion: AIP and its modified indices are significantly negatively associated with all-cause mortality in hypertensive individuals and have a non-linear relationship. No such association was found in the non-hypertensive group. AIP and its modified indices have better predictive ability for all-cause mortality than TyG and its modified indices. These findings provide a scientific basis for the prevention and treatment of cardiovascular diseases in rural areas.
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