ArticleBlood. Red cells & iron2026
Isovolemic hemodilution red cell exchange and blood use in children and young adults with sickle cell disease.
Article in Blood. Red cells & iron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Chronic red blood cell (RBC) transfusions are essential for sickle cell disease (SCD) management, but the cumulative demand for donor RBCs strains blood supplies and increases risks of iron overload and alloimmunization. Isovolemic hemodilution red cell exchange (IHD-RCE) is a 2-step procedure designed to reduce RBC requirements, but its effectiveness remains unclear, particularly in pediatric patients. We conducted a retrospective cohort study of 45 children and young adults with SCD, each receiving standard RCE followed by IHD-RCE, comparing within-patient RBC use between RCE types. Inclusion required ≥6 consecutive standard RCEs and ≥6 consecutive IHD-RCEs within a year of each other. Across 2667 RCE procedures, paired analyses demonstrated both standard and IHD-RCE required a median of 1.2 RBC units per liter of total blood volume (TBV;
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.