Evidence map›Paper›PMID 42338880›Full record

ArticleFrontiers in microbiology2026

Non-lytic protein secretion by virulence-associated Type 10 Secretion Systems in

Srujita Mahankali, Tobias Geiger

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Srujita MahankaliChair of Medical Microbiology and Hospital Hygiene, Max von Pettenkofer-Institute, Ludwig-Maximilians-Universität München (LMU Munich), Munich, Germany.
Tobias GeigerChair of Medical Microbiology and Hospital Hygiene, Max von Pettenkofer-Institute, Ludwig-Maximilians-Universität München (LMU Munich), Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Type 10 Secretion Systems (T10SSs) are critical virulence determinants in many bacterial pathogens and are evolutionarily derived from phage-associated lytic cassettes. In Results and methods: Here, we show that both T10SSs are tightly regulated by specific transcriptional regulators and are expressed exclusively under physiologically relevant inducing conditions. Under these conditions, T10SS activation results in robust expression of the secretion machinery at both the promoter and the protein levels. Population- and single-cell analyses further reveal that induction by environmental cues leads to activation of T10SS expression in the majority of the bacterial population in both Discussion: Despite their origin from phage-derived lytic modules, our data show that

Indexed as

chitinase ASalmonella Typhi (S. Typhi)secretion systemsType 10 Secretion Systemtyphoidal and non-typhoidal Salmonella serovarstyphoid toxinvirulence factors

Identifiers

PMID42338880
PMCPMC13284979

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.