Evidence map›Paper›PMID 42339092›Full record

ArticleFrontiers in endocrinology2026

Widefield SS-OCTA-detected retinal vascular changes and their correlation with DME in diabetes.

Chuanzhen Zheng, Yang Liu, Ruolan Ling, Miao Liu, Wenting Sun, Shiya Tang, Chuntao Lei, Huaqin Xia, Yong Zeng

Abstract read
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In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chuanzhen Zheng *Department of Ophthalmology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Yang Liu *Department of School Hospital, Southwestern University of Finance and Economics, Chengdu, China.
Ruolan Ling *Department of Ophthalmology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Miao LiuDepartment of Ophthalmology, Chengdu Wenjiang District People's Hospital, Chengdu, China.
Wenting SunDepartment of Ophthalmology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Shiya TangDepartment of Ophthalmology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Chuntao LeiDepartment of Ophthalmology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Huaqin XiaDepartment of Ophthalmology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Yong ZengDepartment of Ophthalmology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study investigated retinal blood flow alterations in diabetic macular edema (DME) using ultra-widefield optical coherence tomography angiography (OCTA). Methods: We enrolled 31 healthy controls (NC, 56 eyes), 40 diabetes patients without diabetic retinopathy (DM, 79 eyes), 25 non-proliferative diabetic retinopathy patients (NPDR, 47 eyes), and 42 DME patients (DME, 54 eyes). OCTA images were analyzed using five-quadrant and concentric zonal divisions to assess vascular density (VD) in the superficial (SVC) and deep vascular complexes (DVC). Results: In the DM group, nasal SVC VD was significantly reduced in the N11, N16, and N21 regions. NPDR patients showed widespread SVC VD reduction compared to controls and DM patients, while DME patients exhibited elevated SVC VD in the peripheral retina (11-21 mm). DVC changes were significant only in the macular area in NPDR group, with DME patients showing increased VD in all regions except I21. Peripheral DVC VD (T11, T16, S16) strongly correlated with DME on ROC analysis. Conclusions: Nasal SVC vascular alterations are among the detectable early intergroup differences in preclinical DR, and peripheral DVC VD is closely correlated with the presence of DME.

Indexed as

Diabetes MellitusDiabetic RetinopathyFluorescein AngiographyMacular EdemaRetinal VesselsTomography, Optical CoherenceAdultAgedCase-Control StudiesFemaleHumansMaleMicrovascular DensityMiddle AgedRetrospective Studiesdeep vascular complexdiabetic macular edemaoptical coherence tomography angiographysuperficial vascular complexvascular densitywidefield

Identifiers

PMID42339092
PMCPMC13283875

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.