ArticleGut microbes reports2026
Species-level virome profiling reveals compositional differences in the gut prokaryotic DNA virome of people with HIV-1 on antiretroviral therapy.
Article in Gut microbes reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Alterations in the gut bacterial communities are well described in people with HIV-1 (PWH). However, less is known about the gut viral communities (virome). Herein, we performed an exploratory study of the gut DNA virome in PWH receiving antiretroviral therapy (PWH-ART). Virome profiling was performed using two complementary viral taxa identification pipelines, MetaPhlAn4 and Phanta, providing high-resolution taxonomic profiles at the species level. Consistent patterns of the gut DNA virome were obtained with both pipelines, though Phanta identified a greater number of viral taxa at the species level. Most gut DNA viruses were unclassified species, and bacteriophages constituted the majority of identifiable viral populations. Compared to HIV-1 negative controls (
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