Evidence map›Paper›PMID 42339339›Full record

ArticleHemaSphere2026

Real-world, multi-omics validation of the clinical relevance of molecular taxonomy for myelodysplastic syndromes (MDS).

Giulia Maggioni, Gabriele Todisco, Elisabetta Sauta, Luca Lanino, Somedeb Ball, Jan P Bewersdorf, Tariq Kewan, Najla H Al Ali, Pierre Fenaux, Uwe Platzbecker and 79 more

Abstract read
In one paragraph

Article in HemaSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

89 authors.

Giulia MaggioniIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Gabriele TodiscoIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Elisabetta SautaIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Luca LaninoHematology Section, Department of Internal Medicine Yale School of Medicine New Haven USA.
Somedeb BallVanderbilt Ingram Cancer Center and Vanderbilt University School of Medicine Nashville Tennessee USA.
Jan P BewersdorfHematology Section, Department of Internal Medicine Yale School of Medicine New Haven USA.
Tariq KewanHematology Section, Department of Internal Medicine Yale School of Medicine New Haven USA.
Najla H Al AliDepartment of Malignant Hematology H. Lee Moffitt Cancer Center and Research Institute Tampa Florida USA.
Pierre FenauxHôpital Saint-Louis Université Paris Cité Paris France.
Uwe PlatzbeckerUniversitätsklinikum Carl Gustav Carus Dresden Germany.
Valeria SantiniUniversity of Florence Florence Italy.
Zhuoer XieDepartment of Malignant Hematology H. Lee Moffitt Cancer Center and Research Institute Tampa Florida USA.
Andrew M BrunnerLeukemia Program, Massachusetts General Hospital Cancer Center Harvard Medical School Boston Massachusetts USA.
Andrew T KuykendallDepartment of Malignant Hematology H. Lee Moffitt Cancer Center and Research Institute Tampa Florida USA.
John M BennettUniversity of Rochester Medical Center Rochester New York USA.
Rena BucksteinOdette Cancer Centre Sunnybrook Health Sciences Centre Toronto Ontario Canada.
Rafael BejarUniversity of California San Diego La Jolla California USA.
Hetty E CarrawayLeukemia Program, Taussig Cancer Institute Cleveland Clinic Cleveland Ohio USA.
Amy E DeZernThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University Baltimore Maryland USA.
Elizabeth A GriffithsRoswell Park Comprehensive Cancer Center Buffalo New York USA.
Stephanie HaleneHematology Section, Department of Internal Medicine Yale School of Medicine New Haven USA.
Robert P HasserjianMassachusetts General Hospital Boston Massachusetts USA.
Alan F ListPrecision BioSciences Durham North Carolina USA.
Sanam LoghaviDepartment of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA.
Olatoyosi OdenikeUniversity of Chicago Medicine and University of Chicago Comprehensive Cancer Center Chicago Illinois USA.
Eric PadronDepartment of Malignant Hematology H. Lee Moffitt Cancer Center and Research Institute Tampa Florida USA.
Mrinal M PatnaikDepartment of Internal Medicine, Division of Hematology Mayo Clinic Rochester Minnesota USA.
Gail J RobozNew York-Presbyterian/Weill Cornell Medicine New York New York USA.
Maximilian StahlHematology Section, Department of Internal Medicine Yale School of Medicine New Haven USA.
Mikkael A SekeresSylvester Comprehensive Cancer Center University of Miami Miami Florida USA.
David P SteensmaAjax Therapeutics Cambridge Massachusetts USA.
Michael R SavonaVanderbilt Ingram Cancer Center and Vanderbilt University School of Medicine Nashville Tennessee USA.
Justin TaylorSylvester Comprehensive Cancer Center University of Miami Miami Florida USA.
Mina L XuDepartment of Pathology & Laboratory Medicine Yale School of Medicine New Haven Connecticut USA.
David A SallmanDepartment of Malignant Hematology H. Lee Moffitt Cancer Center and Research Institute Tampa Florida USA.
Stephen D NimerSylvester Comprehensive Cancer Center University of Miami Miami Florida USA.
Christopher S HouriganVirginia Tech FBRI Cancer Research Center Washington District of Columbia USA.
Andrew H WeiDepartment of Haematology Peter MacCallum Cancer Centre, Melbourne Victoria Australia.
Alessia CampagnaIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Marta UbezioIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Elena RivaIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Denise VenturaIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Nicole PinocchioIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Matteo ZampiniIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Alessandro BuizzaIRCCS Humanitas Research Hospital Rozzano Milan Italy.ORCID https://orcid.org/0009-0008-5764-1964
Antonio RussoIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Francesco PesceDepartment of Biomedical Sciences Humanitas University Pieve Emanuele Milan Italy.
Saverio D'AmicoIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Gianluca AstiIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Mattia DelleaniIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Erica TravaglinoIRCCS Policlinico San Matteo Pavia Italy.
Cristina A TentoriIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Ivan FerrariIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Alessandra CrespiIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Giulia FiginiIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Maria Di MatteoIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Matteo BrindisiIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Nicla ManesIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Chiara MilanesiIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Laura CrisafulliIRCCS Humanitas Research Hospital Rozzano Milan Italy.
Francesca FicaraIRCCS Humanitas Research Hospital Rozzano Milan Italy.ORCID https://orcid.org/0000-0003-1873-1189
Gastone CastellaniDepartment of Medical and Surgical Sciences-DIMEC University of Bologna Bologna Italy.
Uma M BorateDepartment of Internal Medicine, Division of Hematology The Ohio State University Columbus Ohio USA.
Fabio EfficaceItalian Group for Adult Haematologic Diseases (GIMEMA) Rome Italy.ORCID https://orcid.org/0000-0002-5065-5166
Steven D GoreDivision of Cancer Prevention National Cancer Institute Rockville Maryland USA.
Tae K KimVanderbilt Ingram Cancer Center and Vanderbilt University School of Medicine Nashville Tennessee USA.
Maria Diez-CampeloDepartment of Hematology Hospital Universitario de Salamanca Salamanca Spain.ORCID https://orcid.org/0000-0002-1467-6779
Arjan A van de LoosdrechtDepartment of Hematology VU University Medical Center-Cancer Center Amsterdam Netherlands.
Navel DaverDepartment of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA.
Maria RozmanHospital Clínic Barcelona Barcelona Spain.
Alberto OrfaoDepartment of Hematology Hospital Universitario de Salamanca Salamanca Spain.ORCID https://orcid.org/0000-0002-0007-7230
Sa A WangDepartment of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA.ORCID https://orcid.org/0000-0001-9385-9911
Kathryn FoucarUniversity of New Mexico Albuquerque New Mexico USA.
Marcelo IastrebnerSanatorio Sagrado Corazón Buenos Aires Argentina.
Phillip ScheinbergHospital A Beneficência Portuguesa de São Paulo Sao Paulo Brazil.
Yasushi MiyazakiAtomic Bomb Disease Institute Nagasaki University Nagasaki Japan.
Yazan F MadanatDivision of Hematology and Oncology UT Southwestern Dallas Texas USA.
Aref Al-KaliDepartment of Internal Medicine, Division of Hematology Mayo Clinic Rochester Minnesota USA.
Moshe MittelmannTel Aviv Sourasky Medical Center, Sackler Faculty of Medicine Tel Aviv University Tel-Aviv Israel.
Thomas CluzeauNice University Hospital Nice France.ORCID https://orcid.org/0000-0002-6745-1127
Lionel AdesHôpital Saint-Louis Université Paris Cité Paris France.
Ulrich GermingDepartment of Hematology, Oncology, and Clinical Immunology Heinrich-Heine-University Düsseldorf Germany.
Guillermo Garcia-ManeroDepartment of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA.
Shahram KordastiDepartment of Haematology Guy's Hospital & Comprehensive Cancer Centre, King's College London UK.
Torsten HaferlachMLL Munich Leukemia Laboratory Munich Germany.
Amer M ZeidanHematology Section, Department of Internal Medicine Yale School of Medicine New Haven USA.
Rami S KomrokjiDepartment of Malignant Hematology H. Lee Moffitt Cancer Center and Research Institute Tampa Florida USA.ORCID https://orcid.org/0000-0002-1876-5269
Matteo G Della PortaIRCCS Humanitas Research Hospital Rozzano Milan Italy.ORCID https://orcid.org/0000-0002-6915-5970
An international study on behalf of GenoMed4all, Synthema, and icMDS consortia

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myelodysplastic syndromes (MDS) are clinically and biologically diverse disorders, emphasizing the need for personalized treatment approaches. The International Working Group for Prognostication of MDS (IWG_PM) recently introduced a molecular classification, referred to as the MDS taxonomy, that categorizes patients into 16 subgroups based on 21 gene mutations, 6 cytogenetic abnormalities, and loss of heterozygosity (LOH) at

Identifiers

PMID42339339
PMCPMC13285588

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.