ArticleFrontiers in bioengineering and biotechnology2026
A patient-specific CTA-CFD framework deciphers hemodynamic heterogeneity after fenestrated TEVAR: a pilot study.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Objectives: Despite the widespread use of fenestrated thoracic endovascular aortic repair (TEVAR), clinical outcomes exhibit considerable heterogeneity whose underlying hemodynamic mechanisms remain poorly understood. This study aimed to establish a patient-specific computational framework integrating postoperative computed tomography angiography (CTA) and computational fluid dynamics (CFD) to quantitatively evaluate morpho-hemodynamic alterations after fenestrated TEVAR. Methods: Six aortic dissection patients undergoing TEVAR with left subclavian artery (LSA) fenestration (three Results: Computational analysis revealed that the brachiocephalic trunk was the least affected vessel following TEVAR (median AR Conclusion: This pilot study establishes a patient-specific computational framework that integrates CTA with CFD to decipher post-intervention morpho-hemodynamic alterations. By quantitatively linking stent-induced geometric changes to adverse hemodynamic phenotypes, the demonstrated methodology explores a mechanistic approach for understanding post-surgical outcome disparities, thereby establishing a computational tool for postoperative evaluation. The clinical utility and predictive value of this tool, however, await validation in larger, prospective cohorts.
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