ArticleTurkish journal of ophthalmology2026
MicroRNA Profiles Targeting Angiopoietin-1, Angiopoietin-2, and TEK Receptor Tyrosine Kinase-2 Genes Associated with Angiogenesis in Proliferative Diabetic Retinopathy.
Article in Turkish journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Objectives: This study aims to assess the concentrations of angiopoietin-1, angiopoietin-2, and Tie-2, which are implicated in the pathophysiology of proliferative diabetic retinopathy (PDR), in the vitreous fluid and to evaluate the expression profiles of microRNA (miR)-145-5p, miR-542-3p, miR-5195-3p, miR-126-3p, miR-211-3p, and miR-204-5p. Materials and Methods: The study included 25 patients with PDR and 25 non-diabetic individuals as controls. Vitreous angiopoietin-1, angiopoietin-2, and Tie-2 levels were measured using enzyme-linked immunosorbent assay (ELISA). miRNA expression levels were evaluated using real-time polymerase chain reaction. Results: Vitreous angiopoietin-1 and 2 levels were significantly lower in the PDR group when compared to controls (p<0.05). The PDR group also had a lower angiopoietin-1/angiopoietin-2 ratio and higher Tie-2 levels, but these differences did not reach statistical significance (p>0.05). Significantly higher levels of miR-126-3p and miR-204-5p were detected in the PDR group (p<0.05), whereas miR-211-3p, miR-5195-3p, miR-542-3p, and miR-145-5p did not show statistically significant differences (p>0.05). Conclusion: Our data demonstrate that increased miR-204-5p and miR-126-3p expression may be associated with angiogenesis-related alterations in PDR. These findings provide insight into PDR-related angiogenesis and suggest that these microRNAs may represent potential biomarkers of disease-related vascular alterations.
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