Evidence map›Paper›PMID 42340575›Full record

ArticleGeroScience2026

Associations of daily step counts with cognitive, clinical, and resting-state electroencephalographic measures in patients with cognitive decline due to Alzheimer's disease.

Matteo Carpi, Mina De Bartolo, Veronica Henao Isaza, Giuseppe Noce, Claudio Del Percio, Susanna Lopez, Filippo Carducci, Roberta Lizio, Antonio Pio Afragola, Burcu Bölükbaş and 25 more

Abstract read
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In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Matteo CarpiDepartment of Physiology and Pharmacology, "Vittorio Erspamer", Sapienza University of Rome, P. le A. Moro 5, Rome, 00185, Italy.
Mina De BartoloDepartment of Physiology and Pharmacology, "Vittorio Erspamer", Sapienza University of Rome, P. le A. Moro 5, Rome, 00185, Italy.
Veronica Henao IsazaDepartment of Physiology and Pharmacology, "Vittorio Erspamer", Sapienza University of Rome, P. le A. Moro 5, Rome, 00185, Italy.
Giuseppe NoceIRCCS Synlab SDN, Naples, Italy.
Claudio Del PercioDepartment of Physiology and Pharmacology, "Vittorio Erspamer", Sapienza University of Rome, P. le A. Moro 5, Rome, 00185, Italy.
Susanna LopezDepartment of Physiology and Pharmacology, "Vittorio Erspamer", Sapienza University of Rome, P. le A. Moro 5, Rome, 00185, Italy.
Filippo CarducciDepartment of Physiology and Pharmacology, "Vittorio Erspamer", Sapienza University of Rome, P. le A. Moro 5, Rome, 00185, Italy.
Roberta LizioDepartment of Physiology and Pharmacology, "Vittorio Erspamer", Sapienza University of Rome, P. le A. Moro 5, Rome, 00185, Italy.
Antonio Pio AfragolaDepartment of Physiology and Pharmacology, "Vittorio Erspamer", Sapienza University of Rome, P. le A. Moro 5, Rome, 00185, Italy.
Burcu BölükbaşDepartment of Physiology and Pharmacology, "Vittorio Erspamer", Sapienza University of Rome, P. le A. Moro 5, Rome, 00185, Italy.
Federica FiorentinoDepartment of Physiology and Pharmacology, "Vittorio Erspamer", Sapienza University of Rome, P. le A. Moro 5, Rome, 00185, Italy.
Angelo BaroneDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana," Neuroscience Section, University of Salerno, Baronissi, Italy.
Arianna CappielloDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana," Neuroscience Section, University of Salerno, Baronissi, Italy.
Federico Di FilippoDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana," Neuroscience Section, University of Salerno, Baronissi, Italy.
Dora RiemmaDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana," Neuroscience Section, University of Salerno, Baronissi, Italy.
Giuliana CostanzoDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana," Neuroscience Section, University of Salerno, Baronissi, Italy.
Roberta BiundoDepartment of General Psychology, University of Padua, Padua, Italy.
Simone CauzzoPadua Neuroscience Center (PNC), University of Padua, Padua, Italy.
Eleonora FiorenzatoPadua Neuroscience Center (PNC), University of Padua, Padua, Italy.
Francesca VianelloPadua Neuroscience Center (PNC), University of Padua, Padua, Italy.
Milena SpoaPadua Neuroscience Center (PNC), University of Padua, Padua, Italy.
Fabrizio StocchiIRCCS San Raffaele Roma, Rome, Italy.
Chiara ColettiIRCCS San Raffaele Roma, Rome, Italy.
Laura VaccaIRCCS San Raffaele Roma, Rome, Italy.
Francesco InfarinatoIRCCS San Raffaele Roma, Rome, Italy.
Paola RomanoIRCCS San Raffaele Roma, Rome, Italy.
Fabiana RadicatiIRCCS San Raffaele Roma, Rome, Italy.
Maria Francesca De PandisSan Raffaele Open University, Rome, Italy.
Simone MarzialiIRCCS San Raffaele Roma, Rome, Italy.
Franco GiubileiDepartment of Neuroscience, Mental Health, and Sensory Organs, Sapienza University of Rome, Rome, Italy.
Lavinia NardaDepartment of Neuroscience, Mental Health, and Sensory Organs, Sapienza University of Rome, Rome, Italy.
Laura ZiccardiDepartment of Neuroscience, Mental Health, and Sensory Organs, Sapienza University of Rome, Rome, Italy.
Angelo AntoniniIRCCS San Camillo Hospital, Venice, Italy.
Paolo BaroneIRCCS Synlab SDN, Naples, Italy.
Claudio BabiloniDepartment of Physiology and Pharmacology, "Vittorio Erspamer", Sapienza University of Rome, P. le A. Moro 5, Rome, 00185, Italy. claudio.babiloni@uniroma1.it.ORCID http://orcid.org/0000-0002-5245-9839

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sedentary behavior is a recognized and modifiable risk factor for cognitive decline and dementia across neurodegenerative conditions. This study used a smartwatch-based telemonitoring procedure combined with ecological cognitive assessment to examine whether step counts can capture sedentary behavior and its association with cognitive functioning in patients with mild cognitive impairment (ADMCI) and dementia (ADD) due to Alzheimer's disease. Then, 19 ADD, 28 ADMCI, and 23 cognitively unimpaired older adults (Nold) were consecutively recruited. Participants underwent clinical assessment, resting-state electroencephalography (rsEEG), and neuropsychological testing. They were then monitored at home for approximately one week using Samsung Galaxy Watch 4-6 devices recording step counts (total, purposeful, and incidental) and activity intensity (peak 30-min cadence), together with the unsupervised SmartMe&You-TELEMAIA serious videogame battery administered on a commercial tablet for cognitive assessment. The ADD group showed reduced step counts and lower peak cadence than both ADMCI and Nold participants, whereas rsEEG markers and cognitive measures discriminated the three groups with a graded pattern. Within the AD sample, smartwatch-derived activity metrics were associated with cognitive functioning as assessed by conventional neuropsychological testing and ecological serious videogame performance, but showed limited associations with rsEEG rhythms. EEG delta and alpha rhythms were also more abnormal in the ADD group than in the ADMCI group. Home-based daytime activity monitoring with commercial smartwatches indicated that step volume and intensity are associated with cognitive status in patients with ADMCI and ADD. These findings suggest that smartwatch-derived activity metrics may provide feasible and cost-effective markers of everyday functioning in Alzheimer's disease.

Indexed as

Alzheimer’s diseaseCognitive declinePhysical activity monitoringResting-state EEGStep countsTelemonitoring

Identifiers

PMID42340575

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.