Evidence mapPaperPMID 42340576Full record

ArticleGeroScience2026

Exploring the association between common genetic deletions and aging: insights from the Canadian Longitudinal Study on Aging.

Ana Lucia Rivera-Herrera, Michèle Rouleau, Mahukpe Narcisse Ulrich Singbo, Tania Cuppens, Pierre-Hugues Carmichael, Arnaud Droit, David Simonyan, Danielle Laurin, Chantal Guillemette

Abstract read
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In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ana Lucia Rivera-HerreraFaculty of Pharmacy, Université Laval, Québec, QC, Canada.ORCID http://orcid.org/0000-0002-5362-7048
Michèle RouleauFaculty of Pharmacy, Université Laval, Québec, QC, Canada.ORCID http://orcid.org/0000-0002-2357-1848
Mahukpe Narcisse Ulrich SingboCentre Hospitalier Universitaire (CHU) de Québec Research Center - Université Laval, Québec, QC, Canada.ORCID http://orcid.org/0000-0002-5009-2420
Tania CuppensUniversité Laval Cancer Research Center, Québec, QC, Canada.ORCID http://orcid.org/0000-0002-7121-0107
Pierre-Hugues CarmichaelCIUSSS de La Capitale-Nationale, Québec, QC, Canada.ORCID http://orcid.org/0000-0002-5324-862X
Arnaud DroitUniversité Laval Cancer Research Center, Québec, QC, Canada.ORCID http://orcid.org/0000-0001-7922-790X
David SimonyanCentre Hospitalier Universitaire (CHU) de Québec Research Center - Université Laval, Québec, QC, Canada.ORCID http://orcid.org/0000-0001-8826-7428
Danielle LaurinFaculty of Pharmacy, Université Laval, Québec, QC, Canada.ORCID http://orcid.org/0000-0001-5032-2452
Chantal GuillemetteFaculty of Pharmacy, Université Laval, Québec, QC, Canada. chantal.guillemette@crchudequebec.ulaval.ca.ORCID http://orcid.org/0000-0002-1113-1212

Funding

Canada Excellence Research Chairs, Government of Canada CRC-2020-00067Canada Foundation for Innovation John R. Evans Leaders Funds #34272CIHR FRN-167269CIHR FRN-187247CIHR LSA94473
6 · The paper itself

Abstract

Germline deletions of UDP-glycosyltransferase (UGT) UGT2B17 and UGT2B28 genes are common in human populations, yet their association with aging remains unclear. In this exploratory study, we analyzed data from 12,934 participants, mostly Caucasian, in the Canadian Longitudinal Study on Aging (CLSA) to assess cross-sectional and prospective associations between UGT deficiencies and aging-related health outcomes, including mortality, multimorbidity, allostatic load, disease burden and polypharmacy. Sex-specific associations emerged from cross-sectional analyses: UGT2B17-deficient males were less likely to report arthritis (adjusted odds ratio (OR

Indexed as

AgingAllostatic loadCLSAGlycosyltransferasePhysiological dysregulationSex-specific agingStructural genetic variationUGT2B17UGT2B28

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.