Evidence map›Paper›PMID 42340596›Full record

ReviewAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2026

Interfacial engineering for enantioselective electrochemical sensing of tryptophan: materials, recognition strategies, and performance benchmarking.

Alvin Lim Teik Zheng, Ellie Yi Lih Teo, Omar Faruqi Marzuki, Supakorn Boonyuen, Eric Lim Teik Chung, Kar Ban Tan, Yoshito Andou

Abstract readReview
PubMed Publisher
In one paragraph

Review in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alvin Lim Teik ZhengInstitute of Ecoscience Borneo, Universiti Putra Malaysia Sarawak, 97008, Bintulu, Sarawak, Malaysia. alvinltz@upm.edu.my.ORCID http://orcid.org/0000-0001-5071-0156
Ellie Yi Lih TeoDepartment of Science and Technology, Faculty of Humanities, Management and Science, Universiti Putra Malaysia Sarawak, 97008, Bintulu, Sarawak, Malaysia.
Omar Faruqi MarzukiDepartment of Science and Technology, Faculty of Humanities, Management and Science, Universiti Putra Malaysia Sarawak, 97008, Bintulu, Sarawak, Malaysia.
Supakorn BoonyuenDepartment of Chemistry, Faculty of Science and Technology, Thammasat University, Pathumthani, 12120, Thailand. chemistrytu@gmail.com.
Eric Lim Teik ChungDepartment of Animal Science, Faculty of Agriculture, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
Kar Ban TanDepartment of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
Yoshito AndouDepartment of Biological Functions Engineering, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu, Kitakyushu, Fukuoka, 808-0196, Japan.

Funding

Universiti Putra Malaysia GPB/9832200
6 · The paper itself

Abstract

The enantioselective detection of biologically active molecules is a vital analytical challenge, particularly for tryptophan (Trp), where the L- and D-enantiomers exhibit distinct physiological functions despite their near-identical properties. Electrochemical (EC) sensing offers a powerful solution, providing high sensitivity and miniaturization potential suitable for in situ monitoring. This review examines the state-of-the-art in EC chiral sensing of Trp, focusing on the integration of functional modifiers such as cyclodextrins (CDs), metal-organic frameworks (MOF), polymers/biopolymers, biomolecules and functional nanomaterials. We deconstruct the molecular recognition mechanisms focusing on enantioselectivity, including hydrogen bonding, π-π interactions, and steric complementarity, supported by theoretical modelling and experimental benchmarking. Furthermore, we evaluate emerging trends including microfluidic integration and AI-assisted signal processing while critically assessing current limitations in sensor stability and reproducibility. By linking interfacial mechanisms to sensing performance, this work provides comprehensive guidance for the rational design of EC platforms for point-of-care and environmental applications.

Indexed as

Electrochemical TechniquesTryptophanBenchmarkingStereoisomerismTryptophanChiral modifiersElectrochemical chiral sensingEnantioselective detectionMolecular recognition mechanismsTryptophan enantiomers

Identifiers

PMID42340596

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.