Light-based footprinting of a eukaryotic genome.

Linnea Ögren, Isabella Muylaert, Kerryn Elliott, Erik Larsson

Abstract read

In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Linnea ÖgrenDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, SE-405 30 Gothenburg, Sweden.ORCID 0009-0002-1836-6660

Isabella MuylaertDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, SE-405 30 Gothenburg, Sweden.ORCID 0009-0007-1476-5724

Kerryn ElliottDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, SE-405 30 Gothenburg, Sweden.ORCID 0000-0001-9238-7879

Erik LarssonDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, SE-405 30 Gothenburg, Sweden.ORCID 0000-0003-1400-0119

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identification of protein-bound DNA sites is key to understanding genome function and regulation, but studying protein-DNA interactions in living, unperturbed cells remains challenging. UV footprinting has been used to study such interactions in vivo by detecting changes in DNA photoproduct formation at protein-bound sites, but only on a limited scale. Here, we describe whole-genome deamination sequencing (Deam-seq), wherein photoproducts (pyrimidine dimers) induced by UV irradiation are revealed as mutations, enabling generation of quantitative photofootprints of the yeast

Indexed as

DNA FootprintingGenome, FungalSaccharomyces cerevisiaeBinding SitesDNA-Binding ProteinsDNA DamageDNA, FungalLightPyrimidine DimersSaccharomyces cerevisiae ProteinsUltraviolet RaysDNA-Binding ProteinsDNA, FungalPyrimidine DimersSaccharomyces cerevisiae Proteins

Identifiers

PMID42341124

DOI10.1126/sciadv.aec0059

PMCPMC13292941

What Socratic holds

Textmetadata

LicenceCC BY-NC

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.